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71 Member Publications for March

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JUNO-coated beads as a functional assay to capture and characterize fertilization-competent human sperm.
1. Hum Reprod Open - published March 9, 2026
2. Cots-Rodríguez P, Wang X, Sanchez-Tudela M, Siu KK, Yip P, Gómez E, Lee JE, Hamze JG, Jiménez-Movilla M
Glycoside hydrolases enhance antibiotic activity against Pseudomonas aeruginosa biofilms from cystic fibrosis airways.
1. Microbiol Spectr - published March 9, 2026
2. Martin I, Chung J, Raju D, Yau Y, Morris AJ, Eisha S, Howell PL, Waters V
Protein abundance inference via expectation-maximization in fluorosequencing.
1. Bioinform Adv - published March 9, 2026
2. Kipen J, Smith MB, Blom T, Zhou SB, Marcotte EM, Jaldén J
The deubiquitinating enzyme Otu1 releases substrates from the conserved initiation complex of the Cdc48/p97 ATPase for proteasomal degradation.
1. Sci Rep - published March 7, 2026
2. Li H, Guan H, Rapoport TA
Human RIG-I Antiviral Deficiency Caused by a Dominant-Negative Variant Locked in a Signaling-Inactive State.
1. medRxiv - published March 6, 2026
2. Solotchi M, Jing H, Gebauer E, Novick SJ, Pascal BD, Tung W, Hanpude P, Madura T, Zhang Y, Alba C, Saracino A, Laghetti P, Shaw ER, Rosen LB, Holland SM, Lisco A, Dalgard CL, Marcotrigiano J, Griffin PR, Su HC, Patel SS
Direct Measurement of Protein Pair Interaction Potential.
1. ACS Nano - published March 6, 2026
2. Poliukhina E, Ong Q, Demurtas D, Uchikawa E, Shafie N, Stellacci F
Discovery of BBO-11818, a Potent and Selective Noncovalent Inhibitor of (ON) and (OFF) KRAS with Activity against Multiple Oncogenic Mutants.
1. Cancer Discov - published March 6, 2026
2. Stahlhut C, Maciag AE, Sullivan KA, Singh K, Gitego N, Zhang Z, Chan AH, Sharma AK, Alexander PA, Shu J, Yang Y, Rigby M, Ma R, Setoodeh S, Smith BP, Pei J, Rabara D, Larsen EK, Turner DM, Zhang C, Feng C, Feng S, Stice JP, Xu R, Lin K, Stephen AG, Lightstone FC, Ji C, Wang K, Simanshu DK, Nissley DV, Wallace E, Wang B, Sinkevicius KW, McCormick F, Beltran PJ
Decoding the Glycan Shield: Immune Recognition and Response to the HIV-1 Envelope Trimer.
1. J Biol Chem - published March 6, 2026
2. Nawaz Z, Adams T, Demirturk ME, Avci FY
Editorial: Modeling the immune system: from PK/PD to systems immunology.
1. Front Immunol - published March 5, 2026
2. Alfonso-González L, Fernández FJ, Vega MC
Structural modeling reveals phage proteins that manipulate bacterial immune signaling.
1. Science - published March 5, 2026
2. Tal N, Hadary R, Chang RB, Osterman I, Jacobson R, Yirmiya E, Bechon N, Hochhauser D, López Rivera M, Madhala B, Garb J, Goldsmith M, Wein T, Kranzusch PJ, Amitai G, Sorek R
A Dual-Model Machine Learning Framework for Interpretable Design and Ensemble Prediction of C-Amidated Antimicrobial Peptides.
1. ACS Appl Mater Interfaces - published March 5, 2026
2. Le DH, Zhu Y, Zhang T, Li W, Hung A, Houshyar S, Le TC
High-Resolution Quantification of Two-Way Nanobody Synergy Using Automated Liquid Handling and Computational Modeling.
1. Bio Protoc - published March 5, 2026
2. Bourgeois NM, Bell SW, Olivier JP, Rout MP, Aitchison JD, Mast FD
Mechanism of co-transcriptional cap snatching by influenza polymerase.
1. Nature - published March 4, 2026
2. Rotsch AH, Li D, Dupont M, Krischuns T, Neef U, Oberthür C, Stelfox A, Lukarska M, Fianu I, Lidschreiber M, Naffakh N, Dienemann C, Cusack S, Cramer P
Recurrent SARS-CoV-2 Omicron broadly neutralizing humanized antibodies in different single human V(H)1-2-rearranging mouse models.
1. Proc Natl Acad Sci U S A - published March 3, 2026
2. Batra H, Luo S, Saunders KO, Higgins JS, Jian F, Zhang J, Kibria MG, Jonaid GM, Zhou QJ, Eaton A, Cronin K, Mallory ML, Mattocks M, Edwards RJ, Parks R, Lee EM, Ye AY, Williams AC, Jung G, Mansouri K, Alam SM, Montefiori DC, Tian M, Baric RS, Cao Y, Haynes BF, Chen B, Alt FW
Evolutionary remodeling of a remnant GET pathway factor into PEX38, an essential peroxin.
1. Proc Natl Acad Sci U S A - published March 3, 2026
2. Krishna CK, Gaussmann S, Das H, Jung M, Oeljeklaus S, Sattler M, Warscheid B, Kalel VC, Erdmann R
Hour-scale single-molecule imaging reveals dynamic assembly of the Wnt co-receptors LRP6 and ROR2 into common signalosomes.
1. Sci Signal - published March 3, 2026
2. Philippi M, Dohle J, Watrinet I, Holtmannspötter M, Miao Y, Li J, Birkholz O, Rothbauer U, Garcia KC, Kurre R, Piehler J, You C
Autologous neutralizing antibodies and polyfunctional T cells contribute to long-term HIV-1 post-intervention control.
1. Nat Immunol - published March 3, 2026
2. Fisher K, Garcia MA, Frattari GS, Naasz C, Zhuo J, Rosás-Umbert M, Dietz LL, Juhl AK, Falling Iversen E, Olesen R, Schleimann MH, Pahus MH, Johansen IS, Henderson M, Carrere L, Roseto I, Gao C, Yu XG, Fray EJ, Aydin B, Lubbeck D, Lai J, Simonetti FR, Danesh A, Miller I, Mendoza P, Niessl J, Gaebler C, Seaman MS, Kaufmann DE, Lehmann C, Gruell H, Klein F, Caskey M, Nussenzweig MC, Tolstrup M, Jones RB, Gunst JD, Siliciano JD, Lichterfeld M, Siliciano RF, Søgaard OS
AI-guided prefusion stabilization of the human coronavirus OC43 spike protein enables universal embecovirus antigen design.
1. PLoS Pathog - published March 2, 2026
2. Melchers JM, Juraszek J, Hulswit RJG, van Overveld D, Le L, van Kuppeveld FJM, Hurdiss DL, Bosch BJ, Langedijk JPM, Bakkers MJG
Synthesis of siRNAs containing carbocyclic nucleotides and the role of cyclopentane conformation in RNAi activity.
1. RSC Chem Biol - published March 2, 2026
2. Kundu J, Datta D, Akabane-Nakata M, Mandal S, Krampert M, Egli M, Manoharan M
The E3-ome gene-centric compendium reveals the human E3 ligase landscape.
1. Cell - published March 2, 2026
2. Chua NK, González-Robles TJ, Reddington CJ, Dudley-Fraser J, Birkinshaw RW, Han J, Solano A, Wong SW, Kochańczyk T, Peter JJ, Nakasone MA, Aust F, Munro J, Tong YH, Iskander J, Abeysekera W, Garnham A, Huckstep H, Ritchie ME, Wertz I, Hymowitz S, Kumar S, Conaway RC, Privé GG, Bullock AN, Babon JJ, Klevit RE, Lorenz S, Ciulli A, Fischer ES, Thomä NH, Nowak RP, Schulman BA, Rapé M, Rittinger K, Pagan JK, Bahlo M, Mackay JP, Mace PD, Lima CD, Hay RT, Komander D, Lechtenberg BC, Joazeiro CAP, Pagano M, Hofmann K, Feltham R
Multiomic analysis of ART-interruption cohorts identifies cell-extrinsic and -intrinsic mechanisms driving lymphocyte-mediated control of HIV rebound.
1. Immunity - published March 2, 2026
2. Ma T, George AF, Li Z, Thomas R, Yin K, Shin MG, Montano M, Matsui Y, Ashokkumar M, Young K, Prigann J, Frouard J, Leddy S, Adiba M, Herrde C, Lange UC, Feschotte C, Nixon DF, Browne EP, Archin NM, Li JZ, Smith D, Deeks S, Søgaard OS, Tolstrup M, Lee S, Pillai SK, Abdel-Mohsen M, Pollard KS, Siliciano R, Ott M, Greene WC, Roan NR
Insights into the structure and evolution of the human SAGA complex by affinity-ligand purification.
1. Sci Adv - published March 2, 2026
2. Damilot M, Schoeps T, Tora L, Schultz P, Lebeau L, Papai G, Ben-Shem A
Surface Morphometrics reveals local membrane thickness variation in organellar subcompartments.
1. J Cell Biol - published March 2, 2026
2. Medina M, Chang YT, Rahmani H, Frank M, Khan Z, Fuentes D, Heberle FA, Waxham MN, Barad BA, Grotjahn DA
Transcription of HIV-1 is heterogenous among authentic latent CD4+ T cell clones.
1. J Exp Med - published March 2, 2026
2. Bittar C, Teixeira AR, Oliveira TY, Silva Santos GS, Lenart K, Fumagalli MJ, Weymar GHJ, Kaczynska A, Linden NL, Ferreira IATM, Caskey M, Jones RB, Jankovic M, Nussenzweig MC
Epitope-spanning antigenic variation reprograms immunodominance and broadens immunity in sequential influenza vaccination.
1. Nat Commun - published March 2, 2026
2. Wan XF, Guan M, Balamalaliyage P, Chen H, Prasai K, Alcala A, Driver J, Olivier AK, Gu W, Frymire C, Madrid DMC, Gao C, Wang C, Li T, Tunterak W, Yang Q, Ramesh A, Ali M, Smith D, Li L, Sant AJ, Hang J, Xie H, Zhou M, Tao YJ
Protein-Linker Co-engineering for Broad-Spectrum Antiviral Development against Enveloped Viruses.
1. ACS Mater Lett - published March 2, 2026
2. Wei L, Loynachan CN, Mathez G, Zhu Y, Liao S, Zwygart AC, Menin L, Tapparel C, Cagno V, Stellacci F
Structural characterization of the Cu(II)-NTA spin label on α-helices by X-ray crystallography and electron paramagnetic resonance.
1. Structure - published March 2, 2026
2. Besaw JE, Reichenwallner J, Chen EY, Hermet-Teesalu P, Tregubenko A, Kim K, Morizumi T, Ustav M Jr, Ernst OP
Copper deprivation reprograms antioxidant defense to suppress ferroptosis via SLC7A11.
1. Redox Biol - published March 1, 2026
2. Xue Q, Chen Z, Yang J, Ren K, Li X, Chen X, Yan D, Wang Y, Tang D, Liu J, Chen X
Proteomic pathways mediating low socioeconomic status and cardiovascular events in older adults in CHS and ARIC.
1. Atherosclerosis - published March 1, 2026
2. Odden MC, Liu X, Shah AM, Yang Y, Lamberson V, Brody JA, Sitlani CM, Huber M, Kalani R, Shojaie A, Raffield LM, Glover L, Palta P, Kucharska-Newton AM, Psaty BM, Floyd JS
Discovery of Covalent Ligands with AlphaFold3.
1. J Am Chem Soc - published March 1, 2026
2. Shamir Y, Gabizon R, Rogel A, Lin DY, Andreotti AH, London N
Best Practices in Structural Ensemble Analysis: Avoiding Pitfalls, Interpreting Results, and Automating Workflows with EnsembleFlex.
1. Curr Protoc - published March 1, 2026
2. Schneider M, Marquez JA, Leach AR
Molecular mechanism of menthol-induced TRPV5 channel inhibition.
1. Nat Commun - published March 1, 2026
2. Méndez-Reséndiz A, De Jesús-Pérez JJ, Rangel-Yescas GE, Rosenbaum T, Moiseenkova-Bell V, Islas LD
Structure of an initiation complex of mycobacterial helicase-nuclease AdnAB at a blunt double-strand break reveals local melting that engages the 3' tracking strand at the ratchet pawl of the helicase motor.
1. Nucleic Acids Res - published March 1, 2026
2. Warren GM, Jason de la Cruz M, Goldgur Y, Shuman S
Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering.
1. Science - published March 1, 2026
2. Chen X, Mao Z, Kolawole EM, Persechino M, Jude KM, Ogishi M, Mo KC, McLaughlin J, Cheng D, Xiang X, Yang X, Gee C, Liu S, Yang A, Obenaus M, Wang N, Noguchi M, Stoyanova T, Lee JK, Good Z, Latorraca NR, Evavold BD, Witte ON, Garcia KC
SAMHD1 depletion restricts SARS-CoV-2 infection by suppressing HNF1-dependent ACE2 expression in lung epithelial cells.
1. PLoS Pathog - published March 1, 2026
2. Cheung PH, Chan P, Yang H, Ambrus K, Honne S, Kim B, Perlman S, Wu L
Structure and dynamics of 2x(CENP-A/H4)(2) octasome reveal a possible intermediate in centromeric chromatin.
1. Life Sci Alliance - published March 1, 2026
2. Ali-Ahmad A, Mors M, Carrer M, Li X, Bilokapić S, Halić M, Cascella M, Sekulić N
Microstructural analysis of the human ventricular myocardium in subjects with Type-II Diabetes.
1. Biochem Biophys Rep - published March 1, 2026
2. Keerthi H, Ramirez SP, Corral MM, Hernandez de Estrada I, Dorado ZN, Gobinath C, Esparza AE, Poon W, Joddar B
Breaking barriers: transitioning from X-ray crystallography to cryo-EM for structural studies.
1. Acta Crystallogr D Struct Biol - published March 1, 2026
2. Zafar H, Malone KL, Singh AK, Cianfrocco MA, Glass KC
Crystal structure of carbon-nitrogen hydrolase from Helicobacter pylori G27.
1. Acta Crystallogr F Struct Biol Commun - published March 1, 2026
2. Srivastava A, Ayanlade JP, Suleiman L, Udell H, Abendroth J, Lorimer DJ, Edwards TE, Staker BL, Zigweid R, Subramanian S, Myler PJ, Chakafana G, Asojo OA
Application of differential scanning fluorimetry to X-ray protein crystallography.
1. IUCrJ - published March 1, 2026
2. Sato Y, Senda T
Bias in the AlphaFold3 prediction of ligand-induced domain motion in enzymes.
1. Proc Natl Acad Sci U S A - published March 1, 2026
2. Yu H, Bekar-Cesaretli AA, Lazou M, Kozakov D, Joseph-McCarthy D, Vajda S
Reverse vaccinology 3.0.
1. Nat Rev Microbiol - published March 1, 2026
2. Andreano E, McLellan JS, Rappuoli R
Advancing the science of nucleic acids together.
1. Mol Ther Nucleic Acids - published March 1, 2026
2. Schiefelbein B, Giangrande PH, Chen Z
Genetically engineered Streptomyces viridosporus ATCC 14672 strains for the discovery of novel moenomycins.
1. Sci Rep - published March 1, 2026
2. Ostash B, Makitrynskyy R, Fedchyshyn M, Luzhetskyy A, Walker S, Fedorenko V
Gut microbiome-produced bile acid metabolite lengthens the circadian period in host intestinal cells.
1. Proc Natl Acad Sci U S A - published March 1, 2026
2. Powell CE, McSween AM, Dohnalová L, Kim CH, Eisert RJ, Sun ZJ, Seo HS, Marquardt V, Dhe-Paganon S, Thaiss CA, Devlin AS
Dynamics of the formation of flat clathrin lattices in response to growth factor stimulus.
1. PLoS Comput Biol - published March 1, 2026
2. Qiao L, Alfonzo-Méndez MA, Taraska JW, Rangamani P
Respiratory syncytial virus mRNA vaccine-induced immunity and protection against subgroups A and B in mice.
1. Immunohorizons - published March 1, 2026
2. Lee S, Yoon J, Shooter S, Pak DS, Ha B, Rostad CA, Anderson LJ, Schinazi RF, Kim B
Facile induction of immune tolerance by an interleukin-2-TGFβ surrogate agonist.
1. Nature - published March 1, 2026
2. Sun Q, Barrett AK, Ogishi M, Lyu H, Jiang H, Liu H, Zhao Y, Rodriguez GE, Tao P, Obenaus M, Householder KD, Tang Q, Lanz TV, Garcia KC
Snapshots of the dynamic basis of NTSR1 G protein subtype promiscuity.
1. Nature - published March 1, 2026
2. Vo AA, Modak A, Lu S, Blanchard SC, Lambert NA, Robertson MJ
AF2BIND: predicting small-molecule binding sites using the pair representation of AlphaFold2.
1. Nat Methods - published March 1, 2026
2. Gazizov A, Lian A, Goverde C, Mou J, Ovchinnikov S, Polizzi NF
Pentameric Architecture of the SARS-CoV-2 Envelope Protein Revealed by SEC-MALS, Cryo-EM, and Molecular Dynamics.
1. J Phys Chem B - published March 1, 2026
2. Weng ZW, Farhat D, Lee JY, Hsu SD
Deep coverage and extended sequence reads obtained with a single archaeal protease expedite de novo protein sequencing by mass spectrometry.
1. Cell Syst - published March 1, 2026
2. Pérez Pañeda L, Kadavá T, Shamorkina TM, Schulte D, Pribil P, Heidelberger S, Narlock-Brand AM, Yannone SM, Snijder J, Heck AJR
Sirtuin 2 inhibits global protein synthesis via Rheb-GTPase degradation.
1. EMBO Rep - published March 1, 2026
2. Shrama A, Zi Y, Pandit AS, Jha K, Sinha VK, Nagesh D, Shivanaiah B, Ravi V, Ghosh S, Khan D, Prabhashankar AB, Sumi TS, Rajpurohit S, Ningaraju S, Raghu S, Srivastava A, Singh M, Lin H, Sundaresan NR
Efficient In Vivo Pharmacological Inhibition of ΔFOSB, an AP-1 Transcription Factor, in the Brain.
1. ACS Chem Neurosci - published March 1, 2026
2. McNeme S, Kumar A, Yim YY, Hughes BW, St Romain C, Li Y, Kumar A, Bao Q, Estill M, Fan S, Takatka N, Chen EP, Rivera M, Chen H, Robison AJ, Machius M, Haggarty SJ, Chin J, Nestler EJ, Zhou J, Rudenko G
A druggable redox switch on SHP1 controls macrophage inflammation.
1. Nat Chem Biol - published March 1, 2026
2. Ng MY, Nix MN, Du G, Davidek I, Burger N, Shin S, Toenjes S, Takeda H, Cheah Xin Yan M, Zhang B, Xiao H, Wei SM, Seo HS, Dhe-Paganon S, Wales TE, Engen JR, Mills EL, Che J, Zhang T, Gray NS, Chouchani ET
Insights into substrate binding and utilization by hyaluronan synthase.
1. Elife - published March 1, 2026
2. Stephens Z, Karasinska J, Zimmer J
Cholecalciferol (vitamin D3) is an agonist of the Alzheimer's disease-associated immune receptor TREM2.
1. Neurotherapeutics - published March 1, 2026
2. Dean HB, Tuckey RA, Greer RA, Greven JA, Yang SZ, Elston DS, Eastep GN, Song Y, Brett TJ, Song Y, Roberson ED
Epitope-focused discovery of SARS-CoV-2 antibodies that potently neutralize Omicron variants.
1. Nat Microbiol - published March 1, 2026
2. Zost SJ, Suryadevara N, Williamson LE, Scheaffer SM, Binshtein E, Buchman CD, Johnson NV, Catanzaro NJ, Ravera S, Chapman NS, Myers L, Ramamohan AR, Handal LS, Nguyen DC, Trivette A, Martinez JR, Villalobos E, Rutherford SA, Eun-Hyung Lee F, Schäfer A, Baric RS, McLellan JS, Diamond MS, Carnahan RH, Crowe JE Jr
Weaker neuroligin 2-neurexin β1 interaction tethers membranes and recruits gephyrin at membrane junctions through clustering.
1. Sci Adv - published March 1, 2026
2. Boyd R, Jaqaman K, Wang W
Multiple roads between the nucleus and the cytoplasm: classes of linear NLSs and NESs and their receptors.
1. Curr Opin Struct Biol - published March 1, 2026
2. Wing CE, Chook YM
Modified protein selection strategy based on Escherichia coli's Hitchhiker transport and validation through selection of nanobodies targeting bovine interferon gamma.
1. Sci Rep - published March 1, 2026
2. Sirimanakul S, Hurley JD, Thaiprayoon A, Intasurat K, Kasemsukwimol W, Submunkongtawee N, Tabtimmai L, Jaengwang K, Choowongkomon K, Riangrungroj P, Leelawattanachai J, Kruse AC, Packthongsuk K, Waraho-Zhmayev D
Genome of an Escherichia coli engineered for improved control over polyhydroxyalkanoate monomer composition.
1. Microbiol Resour Announc - published March 1, 2026
2. Mejia RE, Tran PQ, Kumar D, Fox BG, Majumder EL-W
Predictors of motor outcome with pallidal stimulation for Parkinson's disease from the CSP468 cohort.
1. NPJ Parkinsons Dis - published March 1, 2026
2. D'Souza S, Batheja A, Chen J, Shah HP, Seshadri V, Opem N, Al-Dulaimi O, Toms J, D'Haese P, Dawant BM, Li R, Koch P, Larson P, Holloway KL
Crystal structures reveal phosphorylation-dependent disruption of the HSP70-CHIP interface; a compensatory G132N variant restores binding affinity.
1. Cell Stress Chaperones - published March 1, 2026
2. Stewart M, Paththamperuma C, McCann C, Cottingim K, Zhang H, DelVecchio R, Peng I, Fennimore E, Nix JC, Saeed MN, George K, Makaroff K, Colie M, Paulakonis E, Almeida MF, Afolayan AJ, Brown NG, Page RC, Schisler JC
Mining antibody functionality via AI-guided structural landscape profiling.
1. Nat Commun - published March 1, 2026
2. Terekhov SS, Ivanisenko NV, Zhang N, Mokrushina YA, Nolde DE, Lomakin YA, Zalevsky A, Ovchinnikova LA, Malabuiok DM, Baranova MN, Shashkova T, Aliper E, Zhang M, Guo K, Duga S, Akhmetyanov N, Mamontov S, Smirnova AO, Mamedov I, Bobik TV, Kostin NN, Chernov AS, Eliseev IE, Yaroshevich I, Boitsov VM, Stepanov AV, Zhang D, Efremov RG, Smirnov IV, Kardymon O, Zhang H, Guo Y, Lerner R, Gabibov AG, Kornberg RD
Sanhuang Xiexin Decoction Ameliorates Gastric Ulcers by Activating EGFR/PI3K/AKT Pathway Based on "Drug-Target-Metabolite" Network.
1. J Ethnopharmacol - published March 1, 2026
2. Liu X, Wu X, Wang H, Fang C, Fan B, Wang X, Bai R, Liu Y, Li W, Han L
Functional quinoline-malononitriles for enhanced wound repair and monitoring.
1. Eur J Med Chem - published March 1, 2026
2. Moses R, Ding S, Zhang T, Sloan AJ, Hong Y, Li W
Structural basis of lipid-linked galactan export by the mycobacterial ABC transporter Wzm-Wzt.
1. Nat Commun - published March 1, 2026
2. Garaeva AA, Fabianová V, Savková K, Huszár S, Xue X, Lowary TL, Mikušová K, Seeger MA
Structures of Bacterial and Human Phosphoglycosyltransferases Bound to a Common Inhibitor Inform Selective Therapeutics.
1. ACS Chem Biol - published March 1, 2026
2. Kaudeer BY, Kirsh JM, Mitachi K, Ochoa JM, Soroush-Pejrimovsky MT, Li YE, Nguyen VN, Kurosu M, Clemons WM Jr
Autonomous Synthesis and Scrambling of Phospholipids, Linked to Recycling of Cofactors in Synthetic Cells.
1. ACS Synth Biol - published March 1, 2026
2. Coenradij J, Bailoni E, Lupacchini M, Groenhof WF, Venekamp M, Slotboom DJ, Driessen AJM, Exterkate M, Poolman B
Identification and Validation of an Inhibitor of the Protein Kinases PIM and DYRK.
1. J Med Chem - published March 1, 2026
2. Bencze G, Venkataramani P, Elkayam E, Rivera KD, Garg A, Szabadakai I, Orfi L, Joshua-Tor L, Pappin DJ, Tonks NK