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132 Member Publications for September

Previous Month

Systems immunology: When systems biology meets immunology.
1. Front Immunol - published September 22, 2025
2. Alfonso-González L, Fernández FJ, Vega MC
Structure-based discovery of inhibitors of Mac1 domain of nonstructural protein-3 of SARS-CoV-2 by machine learning-augmented screening of chemical space.
1. bioRxiv - published September 9, 2025
2. Ban F, Ravichandran R, Correy GJ, Herasymenko O, Silva M, Ackloo S, Bolotokova A, Chau I, Gibson E, Harding R, Hutchinson A, Loppnau P, Fraser JS, Schapira M, Cherkasov A, Gentile F
A reversible feedback mechanism regulating mitochondrial heme synthesis.
1. bioRxiv - published September 9, 2025
2. Chitrakar I, Roberson AB, Ayres-Galhardo PH, Brown BL
Factors influencing wound complication risk in maxillofacial injury patients: Insights from a cross-sectional debridement and suturing study.
1. J Tissue Viability - published September 9, 2025
2. Shi Y, Huang C, Diao Y, Liu H, Zhang X, Liu X
Iron-oxide nanoparticles selectively enhance the toxicity of pharmacological ascorbate through hydrogen peroxide-dependent DNA damage in non-small cell lung cancer (NSCLC).
1. Free Radic Biol Med - published September 9, 2025
2. Singhania M, Sho S, Fath MA, Sanchez A, Pulliam CF, Allen BG, Buettner GR, Goswami PC, Spies M, Petronek MS, Spitz DR
Repeated emergence of giant microRNA hairpins across invertebrates.
1. Cell Rep - published September 9, 2025
2. Javad-Zada MM, Zou X, Okamura K, Shang R, Garg A, Lee E, Joshua-Tor L, Fromm B, Lai EC
Phenotypic pleiotropy of missense variants in human B cell confinement receptor P2RY8.
1. Cell Genom - published September 9, 2025
2. LaFlam TN, Billesbølle CB, Dinh T, Wolfreys FD, Lu E, Matteson T, An J, Xu Y, Singhal A, Brandes N, Ntranos V, Manglik A, Cyster JG, Ye CJ
Structure, function and assembly of nuclear pore complexes.
1. Nat Rev Mol Cell Biol - published September 9, 2025
2. Petrovic S, Mobbs GW, Hoelz A
Protective immunity against malaria by a nanoparticle CIS43-based junctional vaccine alone or in combination with R21.
1. bioRxiv - published September 8, 2025
2. Tripathi P, Koo JH, Chen X, Da Silva Pereira L, Dillon M, Zhang B, Lofgren M, Nguyen KT, Teng IT, Bonilla B, Kerscher S, Kong WP, Ransier A, Stephens T, Tsybovsky Y, Weldon SR, Douek DC, Pierson TC, Batista FD, Idris AH, Seder RA, Kwong PD, Zhou T
De novo design of semisynthetic protein nanopores.
1. bioRxiv - published September 8, 2025
2. Schnaider L, Hatstat AK, Scott AJ, Tan SK, Hambley RG, Dawson WM, Griffiths RC, Kormos RC, Melo AA, Tse E, Polizzi NF, Wallace EJ, Merz GE, DeGrado WF
Functional Dissection of the zDHHC Palmitoyltransferase 5-Golgin A7 Palmitoylation Complex.
1. J Biol Chem - published September 8, 2025
2. Kahlson MA, Ritho J, Gomes JV, Wang H, Butterwick JA, Dixon SJ
Michaelis-Menten kinetics of RasGAP proteins by a rapid fluorescence-based assay.
1. Methods - published September 8, 2025
2. Paul ME, Vish KJ, Boggon TJ
The Discovery of RP-2119: A Potent, Selective, and Orally Bioavailable Polθ ATPase Inhibitor.
1. J Med Chem - published September 8, 2025
2. Mochirian P, Papp R, Mathieu MC, Ferraro GB, Dietrich E, Liu B, Bendahan D, Perryman AL, Surprenant S, Fournier S, Barzili BL, Bonneau-Fortin A, Yin SY, Leclaire ME, Patel C, Poirier H, Save S, Mathieu Y, Morin N, Godbout C, Burston HE, Zahn KE, Attia MA, Pinter T, Barabé F, Parikh P, Jagani C, Kang G, Scapin G, Mamane Y, Sfeir A, Mader P, Sicheri F, Zimmermann M, Roulston A, Morris SJ, Black WC, Gallant M
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5' splice sites.
1. bioRxiv - published September 7, 2025
2. Akinyi MV, Yao W, Zeman J, Hipp C, Bartsch D, Heaven L, Le Roux CA, Starner AC, Yuan F, Bartels MD, Zhao F, Ha HL, Sharma R, Choudhary B, Biayna J, Brandes RP, Dumbović G, Ray A, Wittig I, Muench C, Sattler M, Van Nostrand EL, Kurian L
Structural basis for loading of Transcription Repair-Coupling factor Mfd onto stalled elongation complexes.
1. bioRxiv - published September 6, 2025
2. Brewer J, Llewellyn E, Chen J, Campbell EA, Darst SA
Ultrafast Isolation of Synaptic Terminals From Rat Brain for Cryo-Electron Tomography Analysis.
1. Bio Protoc - published September 5, 2025
2. Sun R, Zhou Q
ESCMID workshop: Artificial Intelligence and Machine Learning in Medical Microbiology Diagnostics.
1. Microbes Infect - published September 5, 2025
2. Greutmann M, Borgwardt K, Brüningk S, Franzeck F, Giske CG, Green AG, Guerrero-López A, Ip M, Jutzeler C, Kahles A, Krauthammer M, Macesic N, McFadden B, Meijer E, Moore N, Moran-Gilad J, Lboukili I, Nolte O, Patel R, Schneider G, Seeger MA, Sethi T, Skov RL, Yoon CH, Rodríguez-Sánchez B, Egli A
Photoaffinity Labeling Reveals a Role for the Unusual Triply Acylated Phospholipid N-Acylphosphatidylethanolamine in Lactate Homeostasis.
1. J Am Chem Soc - published September 5, 2025
2. Chiu DC, Cho YT, Lin H, Baskin JM
Selective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordoma.
1. Sci Adv - published September 5, 2025
2. Umbaugh CS, Groth M, Erkut C, Lee KS, Marinho J, Linder S, Iser F, Kapp JN, Schroeter P, Dolaner S, Kayserili A, Helm D, Schneider M, Hartmann J, Walch P, Barth TFE, Mellert K, Dreier B, Schaefer JV, Plückthun A, Fröhling S, Scholl C
Systematic analysis of snRNA genes reveals frequent RNU2-2 variants in dominant and recessive developmental and epileptic encephalopathies.
1. medRxiv - published September 4, 2025
2. Leitão E, Santini A, Cogne B, Essid M, Athanasiadou M, LaFlamme CW, Marijon P, Bernard V, Chatron N, Barcia G, Keren B, Mignot C, Charles P, Besnard T, de Sainte Agathe JM, Fuerte EPA, Sengupta S, Milh M, Ramond F, Allan T, An I, Araujo C, Arpin S, Austin-Tse C, Auvin S, Baer S, Bahi-Buisson N, Bak M, Barth M, Baulac S, Weirauch NB, Begemann M, Bennett MF, Bensabath U, Bézieau S, Bhouri R, Biehler M, Hammer TB, Bogoin J, Bonanno E, Boussion S, Bramswig NC, Bris C, Brosseau-Beauvir A, Bruel AL, Buratti J, Chambon P, Chemaly N, Chesneau B, Colin E, Colmard M, Conrad S, Courtin T, Dang LT, de Saint Martin A, de Vanssay de Blavous Legendre C, Denommé-Pichon AS, DiTroia S, Doco-Fenzy M, Dubourg C, Dubucs C, Ducreux S, Dufour L, Duquet R, Durand B, Chehadeh SE, Elbracht M, Faivre L, Faoucher M, Faudet A, Forlani S, Fradin M, Gaignard P, Ganne B, Garde A, Géraud J, Gill D, Goldenberg A, Grabli D, Grisel C, Gueden S, Gueguen P, Guerrot AM, Guichet A, Härting N, Häusler MG, Heide S, Héron B, Héron D, Heulin M, Houdayer C, Isidor B, Jacquette A, Januel L, Jean-Marçais N, Jousselin K, Kaiser FJ, Kaya S, King C, Konyukh M, Kraft F, Krause J, Kirstetter R, Kuechler A, Kurth I, Labalme A, Laloy JS, Laugel V, Bricquir FL, Lèbre AS, Lebrun M, Leguern E, Levy J, Lieffering N, Lyonnet S, Lüthy K, Macdonald S, Mansour-Hendili L, Maraval J, Mattausch C, Messaoud O, Morel G, Mortreux J, Munnich A, Nabbout R, Nambot S, Navarro V, Neale A, Nguyen L, Nizon M, Nowak F, O'Leary MC, Odent S, Ojeda NM, Olin V, Õunap K, Pais LS, Paluch R, Panagiotakaki E, Patat O, Perrin-Sabourin L, Petit F, Philippe C, Piton A, Planes M, Poirsier C, Pouzet A, Prouteau C, Quéméner-Redon S, Renaud M, Richard AC, Rio M, Rivier C, Robin-Renaldo F, Rollier P, Rossi M, Roubertie A, Rupin M, Saugier-Veber P, Saneto R, Sarrazin E, Schaefer E, Schluth-Bolard C, Schneider A, Schumann I, Seplyarskiy V, Smol T, Sunyaev S, Sperelakis-Beedham B, Stenton SL, Stock F, Tharreau M, Torun D, Toulouse J, Thiyagarajah H, Valence S, Valleix S, Villard L, Ville D, Villeneuve N, Vitobello A, Waernessyckle A, Weber Y, Wieczorek D, Witkowski T, Yadavilli M, Yammine T, Zaafrane-Khachnaoui K, Zaki MS, Ziegler A, Lermine A, Nicolas G, Gleeson JG, Sadleir LG, Hildebrand MS, Scheffer IE, Whiffin N, O'Donnell-Luria A, Mefford HC, Blanc P, Thevenon J, Charbonnier C, Charenton C, Depienne C, Lesca G, Nava C
Cryo-EM structure revealed a novel F-actin binding motif in a Legionella pneumophila lysine fatty-acyltransferase.
1. bioRxiv - published September 4, 2025
2. Zeng WW, Komaniecki G, Liu J, Lin H, Mao Y
The Pseudomonas aeruginosa Membrane Histidine Kinase BqsS/CarS Directly Senses Environmental Ferrous Iron (Fe(2+)).
1. bioRxiv - published September 4, 2025
2. Paredes A, Iheacho C, Chacón KN, Smith AT
A choanoflagellate cGLR-STING pathway reveals evolutionary links between bacterial and animal immunity.
1. bioRxiv - published September 4, 2025
2. Li Y, Toyoda HC, Fernandez SG, Tiwari B, McNairy C, Woznica A, Kranzusch PJ
Target RNA recognition drives PIWI(∗) complex assembly for transposon silencing.
1. Mol Cell - published September 4, 2025
2. Portell-Montserrat J, Tirian L, Yu C, Silvestri G, Hohmann U, Handler D, Duchek P, Fin L, Plaschka C, Brennecke J
Genetic suppression of precocious transcription termination identifies mutations in essential subunits of the fission yeast cleavage and polyadenylation machinery.
1. RNA - published September 4, 2025
2. Innokentev A, Sanchez AM, Bednor L, Babor J, Schwer B, Shuman S
Functional Relevance of CASP16 Nucleic Acid Predictions as Evaluated by Structure Providers.
1. Proteins - published September 4, 2025
2. Kretsch RC, Albrecht R, Andersen ES, Chen HA, Chiu W, Das R, Gezelle JG, Hartmann MD, Höbartner C, Hu Y, Jadhav S, Johnson PE, Jones CP, Koirala D, Kristoffersen EL, Largy E, Lewicka A, Mackereth CD, Marcia M, Nigro M, Ojha M, Piccirilli JA, Rice PA, Shin H, Steckelberg AL, Su Z, Srivastava Y, Wang L, Wu Y, Xie J, Zwergius NH, Moult J, Kryshtafovych A
Distance-AF improves predicted protein structure models by AlphaFold2 with user-specified distance constraints.
1. Commun Biol - published September 3, 2025
2. Zhang Y, Zhang Z, Kagaya Y, Terashi G, Zhao B, Xiong Y, Kihara D
Cellular Hallmarks From Volume Electron Microscopy Reveal Developmental Progression of Plasmodium Ookinetes.
1. Adv Sci (Weinh) - published September 3, 2025
2. Darif N, Rheinnecker M, Hildenbrand K, Chookajorn T, Dorner LP, Hériché JK, Henriksson S, Funaya C, Hentzschel F, Sandblad L, Billker O, Schwab Y, Frischknecht F
Distal mutations enhance catalysis in designed enzymes by facilitating substrate binding and product release.
1. Nat Commun - published September 3, 2025
2. Zarifi N, Asthana P, Doustmohammadi H, Klaus C, Sanchez J, Hunt SE, Rakotoharisoa RV, Osuna S, Fraser JS, Chica RA
Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1.
1. Nat Commun - published September 3, 2025
2. Thatavarthy S, Abriata LA, Meireles FTP, Zuccaro KE, Gargey Iragavarapu A, Sullivan GM, Moss FR 3rd, Frost A, Dal Peraro M, Aydin H
CXCR4 mediated recognition of HIV envelope spike and inhibition by CXCL12.
1. Nat Commun - published September 3, 2025
2. Zhang Z, Zhang H, Zheng L, Chen S, Du S, Xiao J, Patel DJ
Multi-Temperature Crystallography of S-Adenosylmethionine Decarboxylase Observes Dynamic Loop Motions.
1. Biomolecules - published September 3, 2025
2. Patel JR, Bonzon TJ, Bakht TF, Fagbohun OO, Clinger JA
Ebola virus VP35 NNLNS motif modulates viral RNA synthesis and MIB2-mediated signaling.
1. Proc Natl Acad Sci U S A - published September 3, 2025
2. Uwase G, Luthra P, Vogel OA, Batra J, La Rosa BA, Sheehan KCF, Khatavkar O, Payton JE, Davey RA, Krogan NJ, Basler CF, Leung DW, Amarasinghe GK
Loss of TET function in T regulatory cells yields ex-Treg cells biased toward T follicular helper cells, causing autoimmune diseases through autoantibody production.
1. bioRxiv - published September 3, 2025
2. Suzuki K, Arteaga-Vazquez LJ, Reveles BV, Hernández-Espinosa L, López-Moyado IF, Onodera A, Samaniego-Castruita D, Ay F, Lara-Custodio A, Hogan PG, Sepulveda H, Rao A
The XBB.1.5 COVID-19 vaccine elicits a durable antibody response to ancestral and XBB.1.5 SARS-CoV-2 spike proteins.
1. Sci Transl Med - published September 3, 2025
2. Kumar S, Jain S, Wali B, Zarnitsyna VI, Joshi D, Ellis ML, Lai L, Malik AA, McPherson TO, Godbole S, Patel A, Linderman S, Solis D, Sahoo MK, Bechnak K, Paredes I, Tanios R, Kazzi B, Dib SM, Litvack MB, Wimalasena ST, Hicks H, Tamin A, Bowen NE, Atherton L, Paden C, Harcourt JL, Wentworth DE, Ciric C, West RH, Rostad CA, Teng IT, Wang D, Ortlund EA, Menachery VD, Edupuganti S, Kwong PD, Rouphael N, Pinsky BA, Douek DC, Moreno A, Wrammert J, Suthar MS
Reconstitution of autophagic-like membrane tethering reveals that Atg11 can bind and cluster vesicles on cargo mimetics.
1. Autophagy - published September 3, 2025
2. Andhare D, Katzenell S, Najera SI, Mauras SC, Bauer KM, Ragusa MJ
Targeting necrotic lipid release in tumors enhances immunosurveillance and cancer immunotherapy of glioblastoma.
1. Cell Res - published September 3, 2025
2. Ji Y, Jiang J, Hu L, Lin P, Zhou M, Hu S, Wang M, Ji Y, Liu X, Yan D, Guo Y, Sathe AA, Evers BM, Xing C, Luo X, Xie Q, Pei W, Zhang Z, Yu H
18-Crown-6-ether Utilizes Distinct Allosteric Interactions to Uncouple Transport by the Multidrug Efflux Pump EmrE.
1. Biochemistry - published September 3, 2025
2. Brousseau M, Dash T, Rourke MJ, Kurauskas V, Tonelli M, Hibbs KM, Buller AR, Marty MT, Henzler-Wildman KA
Structural basis of QueC-family protein function in qatABCD anti-phage defense.
1. bioRxiv - published September 3, 2025
2. Gao A, Wassarman DR, Kranzusch PJ
PARP enzyme synthesis of protein-free poly(ADP-ribose): Implications for DNA damage signaling and repair.
1. DNA Repair (Amst) - published September 2, 2025
2. Langelier MF, Pascal JM
Deep Receptor Scanning Reveals General Sequence Constraints on GPCR Biosynthesis.
1. bioRxiv - published September 2, 2025
2. Tedman A, Goel M, Shah S, Howard MK, Chamness LM, Bonifasi A, Adams I, Gallagher JM, Penn WD, Nemec K, McDonald EF, Corman BN, Robinson JP, Post CB, Clark PL, Babu MM, Manglik A, Kuntz CP, Coyote-Maestas W, Schlebach JP
Structural insights into chemoresistance mutants of BCL-2 and their targeting by stapled BAD BH3 helices.
1. Nat Commun - published September 2, 2025
2. DeAngelo TM, Adhikary U, Korshavn KJ, Seo HS, Brotzen-Smith CR, Camara CM, Dhe-Paganon S, Bird GH, Wales TE, Walensky LD
The long shadow of family-internal and -external adverse childhood experiences: associations with mental functioning in middle-aged and older cancer survivors.
1. J Cancer Surviv - published September 2, 2025
2. Shi J, Ma X, Liu X, Zhao L
Modified unlocked nucleic acid (MUNA) mitigates off-target effects of small interfering RNAs.
1. Nucleic Acids Res - published September 2, 2025
2. Mori S, Datta D, Perkins L, Jung M, Woods LB, Eaton A, Qin J, Racie T, Kim M, Guenther DC, Castoreno A, Schlegel MK, Charisse K, Egli M, Matsuda S, Manoharan M
Selective Detection of a Key Region in Chemotaxis Signaling Protein Complexes by Solid-State NMR.
1. Biophys J - published September 2, 2025
2. Allen JJ, Wang S, Rienstra CM, Thompson LK
Addition of hydroxyurea (hydroxycarbamide) enhances the efficacy of fludarabine/cytarabine-based salvage regimens against acute myeloid leukaemia.
1. Br J Haematol - published September 2, 2025
2. Lilienthal I, Tao S, Nilsson C, Leonard E, Zhang R, Sorteberg AL, Fredrikson L, Xagoraris I, Fard SS, Tsesmetzis N, Zachariadis V, Cai H, Sandhow L, Langebäck A, Bohlin A, Tamm KP, Bengtzén S, Schinazi RF, Lehmann S, Kim B, Rassidakis GZ, Qian H, Jädersten M, Herold N
The Ebolavirus transcriptional regulatory signal equilibrates between two structural conformations to affect VP30 binding.
1. J Mol Biol - published September 2, 2025
2. Edwards JM, Kachale A, McCleery SR, Law GA, Patel V, D'Souza VM, Pham VV
Conformation and Dynamics of Monomeric, Phase-Separated, and Cross-Linked Resilin Biomaterials.
1. J Am Chem Soc - published September 2, 2025
2. Otis JB, Reichenwallner J, Reichheld SE, Au A, Yip CM, Ernst OP, Sharpe S
HIV-induced T cell quiescence and the origins of viral latency.
1. Nat Immunol - published September 2, 2025
2. Li Z, Ott M
Effects of an app-based brief gratitude practice on positive and negative daily affect during the COVID-19 pandemic.
1. Acta Psychol (Amst) - published September 2, 2025
2. Lin S, Shen S, Ivcevic Z, Cheng DR, Probasco R, Silbermann B, Zhang F, Lin X, Brackett M
Scalable deep learning reconstruction for accelerated multidimensional nuclear magnetic resonance spectroscopy of proteins.
1. Sci Adv - published September 2, 2025
2. Huang Y, Gao Y, Tu Z, Agback T, Orekhov V, Hyberts SG, Wagner G, Lin Y, Chen Z, Guo D, Qu X
A single residue in the yellow fever virus envelope protein modulates virion architecture and antigenicity.
1. Nat Commun - published September 2, 2025
2. Bibby S, Jung J, Low YS, Amarilla AA, Newton ND, Scott CAP, Balk J, Ting YT, Freney ME, Liang B, Grant T, Coulibaly F, Young P, Hall RA, Hobson-Peters J, Modhiran N, Watterson D
Comparison of SHAP and clinician friendly explanations reveals effects on clinical decision behaviour.
1. NPJ Digit Med - published September 2, 2025
2. Hur S, Lee Y, Park J, Jeon YJ, Cho JH, Cho D, Lim D, Hwang W, Cha WC, Yoo J
Cache: Utilizing ultra-large library screening in Rosetta to identify novel binders of the WD-repeat domain of Leucine-Rich Repeat Kinase 2.
1. J Cheminform - published September 2, 2025
2. Liessmann F, Eisenhuth P, Fürll A, Vu O, Moretti R, Meiler J
Merging conformational landscapes in a single consensus space with FlexConsensus algorithm.
1. Nat Methods - published September 2, 2025
2. Herreros D, Perez Mata C, Sanchez Sorzano CO, Carazo JM
Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity.
1. Science - published September 2, 2025
2. Wassarman DR, Pfaff P, Paulo JA, Gygi SP, Shokat KM, Kranzusch PJ
Cardiac adaptation to endurance exercise training requires suppression of GDF15 via PGC-1α.
1. Nat Cardiovasc Res - published September 2, 2025
2. Khetarpal SA, Li H, Vitale T, Rhee J, Challa S, Castro C, Pabel S, Sun Y, Liu J, Bogoslavski D, Vargas-Castillo A, Smythers AL, Blackmore KA, Grauvogel L, Mittenbühler MJ, Khandekar MJ, Curtin C, Narvaez-Paliza JM, Wang C, Houstis NE, Sprenger HG, Jurgens SJ, Biddinger KJ, Kuznetsov A, Freeman R, Ellinor PT, Nahrendorf M, Paulo JA, Gygi SP, Dumesic PA, Asnani A, Aragam KG, Puigserver P, Roh JD, Spiegelman BM, Rosenzweig A
Dimerization and dynamics of human angiotensin-I converting enzyme revealed by cryo-EM and MD simulations.
1. Elife - published September 2, 2025
2. Mancl JM, Wu X, Zhao M, Tang WJ
Design of facilitated dissociation enables timing of cytokine signalling.
1. Nature - published September 2, 2025
2. Broerman AJ, Pollmann C, Zhao Y, Lichtenstein MA, Jackson MD, Tessmer MH, Ryu WH, Ogishi M, Abedi MH, Sahtoe DD, Allen A, Kang A, De La Cruz J, Brackenbrough E, Sankaran B, Bera AK, Zuckerman DM, Stoll S, Garcia KC, Praetorius F, Piehler J, Baker D
Collective homeostasis of condensation-prone proteins via their mRNAs.
1. Nature - published September 2, 2025
2. Faraway R, Costello Heaven N, Digby H, Kuret Hodnik K, Rebselj J, Wilkins OG, Chakrabarti AM, Iosub IA, Vadnjal N, Dore R, Knez L, Ameres SL, Plaschka C, Ule J
Structural remodeling of target-SNARE protein complexes by NSF enables synaptic transmission.
1. Nat Commun - published September 2, 2025
2. White KI, Khan YA, Qiu K, Balaji A, Couoh-Cardel S, Esquivies L, Pfuetzner RA, Diao J, Brunger AT
LRP8 is a receptor for tick-borne encephalitis virus.
1. Nature - published September 2, 2025
2. Mittler E, Tse AL, Tran PT, Florez C, Janer J, Varnaite R, Kasikci E, Mv VK, Loomis M, Christ W, Cazares E, Bakken RR, Martin CK, Zeng X, Raymond JL, Shahsavani M, Khanal S, Wilkinson ER, Oktavia RM, Slough MM, Haslwanter D, Han J, Berrigan J, Rosendal E, Kielian M, Manicassamy B, Överby AK, Falk A, Barba-Spaeth G, Rey FA, Klingström J, Gavathiotis E, Herbert AS, Chandran K, Gredmark-Russ S
Cryogenic STEM of thick biological specimens.
1. Nat Methods - published September 2, 2025
2. Sachse C
Molecular interplay between ComEC domains allows for selective degradation of the non-translocating strand during natural transformation.
1. Nucleic Acids Res - published September 2, 2025
2. Stedman MJM, Deselaers S, Braus SAG, Wang D, Balaguer MG, Gossert AD, Hospenthal MK
RNA/DNA-binding protein TDP43 regulates DNA mismatch repair genes with implications for genome stability.
1. Nucleic Acids Res - published September 2, 2025
2. Provasek VE, Bacolla A, Rangaswamy S, Kodavati M, Mitra J, Yusuf IO, Malojirao VH, Vasquez V, Britz GW, Li GM, Xu Z, Mitra S, Garruto RM, Tainer JA, Hegde ML
DHX36 modulates stress granule assembly independent of recruitment of mRNAs with G-quadruplex sequence motifs.
1. Nucleic Acids Res - published September 2, 2025
2. Cheng LY, Ripin N, Cech TR, Parker R
GATA2 mutation is associated with immune dysfunction and increased Mycobacterium haemophilum susceptibility in immunocompromised individuals.
1. JCI Insight - published September 2, 2025
2. Gupta A, Mehta SB, Abhimanyu, Rosa BA, Martin J, Ahmed M, Thirunavukkarasu S, Fatma F, Amarasinghe GK, Mitreva M, Bailey TC, Clifford DB, Khader SA
Structural Dynamics and Topology of Human KCNE3 in Lipid Bilayers Studied by Site-Directed Spin Labeling and Electron Paramagnetic Resonance Spectroscopy.
1. J Phys Chem B - published September 2, 2025
2. Reynolds DB, Campbell C, Scheyer MW, Williams PL, Loka P, Hamilton K, Oriaku O, Damoh I, Guerra Diaz A, Mbey-Ogbonnaya G, Shah PK, Sanders CR, Lorigan GA, Sahu ID
Mutational dissection of HCMV gB and gH cytoplasmic tails highlights conserved and divergent features of fusion regulation.
1. mBio - published September 2, 2025
2. Lee C, DiBella HK, Heldwein EE
Differential effects of sodium on agonist-induced conformational transitions and signaling at μ and κ opioid receptors.
1. bioRxiv - published September 2, 2025
2. Kuijer B, Fulton CJ, Albert TL, Knobloch PM, Wang J, Krumm BE, Che T, Varga BR, Majumdar S, Katritch V, Gumpper RH, Kenakin T, Huang XP, Roth BL
Structurally diverse viral inhibitors converge on a shared mechanism to stall the antigen transporter TAP.
1. Proc Natl Acad Sci U S A - published September 2, 2025
2. Lee J, Manon V, Chen J
Clot Composition and Ischemic Stroke Etiology: A Contemporary Narrative Review.
1. J Clin Med - published September 2, 2025
2. Kosyakovsky J, Rossitto CP, Antonios JP, Renedo D, Stapleton CJ, Sansing LH, Navaratnam DS, Giles JA, Patel AB, Matouk CC, Sujijantarat N
Chromosome-scale genome assembly and gene annotation of the hydrothermal vent annelid Alvinella pompejana yield insight into animal evolution in extreme environments.
1. BMC Biol - published September 2, 2025
2. Hilali SE, Dru P, Le Moan A, Li YI, Huynen MA, Hoelz A, Robinson RC, Martín-Durán JM, Jollivet D, Claridge-Chang A, Copley RR
SHP2 genetic variants in NSML-associated RASopathies disrupt the PZR-IRX transcription factor signaling axis.
1. Proc Natl Acad Sci U S A - published September 2, 2025
2. Perla S, Stiegler AL, Yi JS, Enyenihi L, Zhang L, Riaz M, An E, Qyang Y, Boggon TJ, Bennett AM
Nucleotide- and metalloid-driven conformational changes in the arsenite efflux ATPase ArsA.
1. Proc Natl Acad Sci U S A - published September 2, 2025
2. Mahajan S, Pall AE, Li YE, Stemmler TL, Rees DC, Clemons WM Jr
Structural insights into the vitamin K-dependent γ-carboxylation of osteocalcin.
1. Cell Res - published September 2, 2025
2. Cao Q, Fan J, Ammerman A, Awasthi S, Lin Z, Mierxiati S, Chen H, Xu J, Garcia BA, Liu B, Li W
The nuclear export receptor CRM1/XPO1 and its diverse cargoes.
1. Trends Biochem Sci - published September 2, 2025
2. Kehlenbach RH, Chook YM
FoxP3 forms a head-to-head dimer in vivo and stabilizes its multimerization on adjacent microsatellites.
1. bioRxiv - published September 1, 2025
2. Leng F, Clark R, Zhang W, Viennet T, Arthanari H, Xi W, Hur S
Biochemical characterizations of Pontocerebellar Hypoplasia linked mutations of Target of Egr1 (TOE1) reveal impacts on thermal stability, ribonuclease activity, and oligomerization.
1. bioRxiv - published September 1, 2025
2. Zavala L, Sobien M, Hayne CK
Exploring metalloproteome remodeling in calprotectin-stressed Acinetobacter baumannii using chemoproteomics.
1. bioRxiv - published September 1, 2025
2. Osterberg MK, Bak DW, Andreini C, Critchlow JM, Trinidad JC, Cornish PV, Akizuki T, Chazin WJ, Skaar EP, Weerapana E, Giedroc DP
A borindolizine platform for the design of fluorophores with tunable emissions.
1. Chem Sci - published September 1, 2025
2. Apte CN, Heller NW, Huang BZ, Marr A, Jorner K, Aspuru-Guzik A, Yudin AK
Identification of a broad and potent V3 glycan site bNAb targeting an N332(gp120) glycan-independent epitope.
1. bioRxiv - published September 1, 2025
2. Gieselmann L, DeLaitsch AT, Rohde M, Radford C, Worczinski J, Momot A, Ahmadov E, Burger JA, Havenar-Daughton C, Deshpande S, Giovannoni F, Corti D, Kreer C, Ercanoglu MS, Schommers P, Georgiev IS, West AP Jr, Knüfer J, Stumpf R, Kroidl A, Geldmacher C, Maganga L, William W, Ntinginya NE, Hoelscher M, Yang Z, Wei Q, Renfrow M, Green TJ, Novak J, van Gils MJ, Gristick HB, Gruell H, Bloom JD, Seaman MS, Bjorkman PJ, Klein F
General Trends in the Calnexin-Dependent Expression and Pharmacological Rescue of Clinical CFTR Variants.
1. bioRxiv - published September 1, 2025
2. Tedman A, Olson JA 3rd, Kim M, Foye C, Jackson JJ, McDonald EF, McKee AG, Noguera K, Kuntz CP, Meiler J, Oliver K, Plate L, Schlebach JP
Structural basis for the function of long noncoding RNA Pnky in neural stem cells.
1. bioRxiv - published September 1, 2025
2. Saha P, Patel S, Tavares RC, Choi H, Andersen RE, Tsao LH, Pyle AM, Lim DA
Proteomic Analysis of Sputum from Patients with Active Tuberculosis.
1. Proteomes - published September 1, 2025
2. Marcantonio E, Woron AM, Whelen AC, Prisic S
CryoDataBot: a pipeline to curate cryoEM datasets for AI-driven structural biology.
1. bioRxiv - published September 1, 2025
2. Xu Q, Wu L, Rebelo M, Feng S, Yu X, Farheen F, Kihara D, Zhou ZH
Structure of the Huntingtin F-actin complex reveals its role in cytoskeleton organization.
1. Sci Adv - published September 1, 2025
2. Carpentier R, Kim J, Capizzi M, Kim H, Fäßler F, Hansen JM, Kim MJ, Denarier E, Blot B, Degennaro M, Labou S, Arnal I, Marcaida MJ, Peraro MD, Kim D, Schur FKM, Song JJ, Humbert S
Large Library Docking and Biophysical Analysis of Small-Molecule TMPRSS2 Inhibitors.
1. J Med Chem - published September 1, 2025
2. Fraser BJ, Young NJ, Bender BJ, Gahbauer S, Ilyassov O, Wilson RP, Li Y, Seitova A, Lourenço AL, Chung DH, Bardine C, Bénard F, Shoichet BK, Craik CS, Arrowsmith CH
Illuminating druggable dark matter in RNA virus replication using in situ cryo-EM.
1. Curr Opin Virol - published September 1, 2025
2. Sharma H, Sorin MN, Sharma KB, Carlson LA
Expression and Purification of Austropuccinia psidii Effector Proteins in Escherichia coli.
1. Protein Expr Purif - published September 1, 2025
2. Sullivan JV, Currie MJ, Morris VK, Sethi A, Panjikar S, Smith GR, Meisrimler CN, Dobson RCJ
Desthiobiotin (DTB)-modified and TAMRA-modified 2''OMeNAD(+) are RNA 2'-phosphotransferase (Tpt1) poisons that enable affinity-tagging and fluorescence-tagging of internal RNA 2'-phosphate groups.
1. RNA - published September 1, 2025
2. Kasprzyk R, Ghosh S, Shuman S
Identifying protease-activated targets and exploring therapeutic applications.
1. Expert Opin Ther Targets - published September 1, 2025
2. Kang D, Craik CS
Mutation in enterovirus 71 nonstructural protein 3A increases genome replication fidelity and exhibits attenuated virulence in mice.
1. J Virol - published September 1, 2025
2. Yu F, Xiong D, Zhong Y, Zhang Q-Y, Deng C-L, Zhang Z-R, Wang C, Qiu Y, Ye H-Q, Gong P, Zhang B
Radiosynthesis and Preclinical Evaluation of a Carbon-11 Labeled Phosphodiesterase 7 Inhibitor for PET Neuroimaging.
1. ACS Med Chem Lett - published September 1, 2025
2. Xiao Z, Sun J, Fujinaga M, Wei H, Zhao C, Haider A, Van R, Kuang S, Yamasaki T, Zhang Y, Rong J, Hu K, Chen J, Leon EC, Mori W, Xie L, Wei J, Xu Y, Shao Y, Zhang HT, Xu Y, Ran C, Lloyd KK, Wang L, Zhang MR, Liang SH
Covariation MS uncovers a protein that controls cysteine catabolism.
1. Nature - published September 1, 2025
2. Xiao H, Ordonez M, Fink EC, Covington TA, Woldemichael HB, Chen J, Jain MS, Rohatgi MH, Wei SM, Burger N, Sharif MA, Jan J, Wang Y, Petrocelli JJ, Blackmore K, Smythers AL, Zhang B, Gilbert M, Cheong H, Khetarpal SA, Smith A, Bogoslavski D, Lei Y, Vaites LP, McAllister FE, Van Bruggen N, Donovan KA, Huttlin EL, Mills EL, Fischer ES, Chouchani ET
Chemical and ribosomal synthesis of atropisomeric and macrocyclic peptides with embedded quinolines.
1. Nat Chem - published September 1, 2025
2. Knudson IJ, Dover TL, Dilworth DA, Paloutzian C, Paz O, Lin J, Cho H, Gonen T, Schepartz A, Miller SJ
Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response.
1. Elife - published September 1, 2025
2. San Felipe CJ, Batra J, Muralidharan M, Malpotra S, Anand D, Bauer R, Verba KA, Swaney DL, Krogan NJ, Grabe M, Fraser JS
Discovery of BRD9 Molecular Glue Degraders That Spare Cardiomyocytes.
1. J Am Chem Soc - published September 1, 2025
2. Byun WS, Zhuang Z, Hnatiuk AP, Jin C, Jiang Z, Baek K, Chao E, Donovan KA, Fischer ES, Mercola M, Gray NS
Synthesis and Antiviral Evaluation of Unexplored Dioxolane-Derived 7‑Deazapurine Nucleoside Analogues against Epstein-Barr Virus (EBV).
1. ACS Med Chem Lett - published September 1, 2025
2. Singh US, Jones RA, Kothapalli Y, Lan S, Zhang XQ, Slack RL, Thoomu HP, Schooley RT, Sarafianos SG, Chu CK
Proline stabilizes amphiphilic gold nanoparticles via hydrophobic interactions.
1. Nanoscale Horiz - published September 1, 2025
2. Mao T, Ong Q, Kohlbrecher J, Poliukhina E, Silva PJ, Stellacci F
Delta-type glutamate receptors are ligand-gated ion channels.
1. Nature - published September 1, 2025
2. Wang H, Ahmed F, Khau J, Mondal AK, Twomey EC
Polo-Like Kinase 1 Phosphorylation Tunes the Functional Viscoelastic Properties of the Centrosome Scaffold.
1. Adv Sci (Weinh) - published September 1, 2025
2. Amato M, Hwang JH, Rios MU, Familiari NE, Rosen MK, Woodruff JB
Efficient Synthesis of Chemically Recyclable Polyamides via Substituent Effects-Enabled Mechanistic Pathway.
1. Angew Chem Int Ed Engl - published September 1, 2025
2. Ma Y, Zheng C, Raphaël Bréas D, Slor G, Molleyres APA, Liao Q, Stellacci F
Volatile sulfur compounds in New Zealand Sauvignon blanc: An inter-regional survey.
1. Food Chem - published September 1, 2025
2. Manners SH, van Leeuwen KA, Gaw S, Panicker K, Gill S, Dhami MK, Warden N, Dobson RCJ, Fedrizzi B, Stott MB
Directed or Random? Student Reasoning About Diffusion Across Contexts.
1. Adv Physiol Educ - published September 1, 2025
2. VanDerSlik AL, Scott EE, Wenderoth MP, Kam ZA, Parker JD, Shah MB, Vieregge J, Doherty JH
APOL2 Stabilizes Ku80 to Confer NHEJ-Mediated Radioresistance in Gastric Cancer.
1. Adv Sci (Weinh) - published September 1, 2025
2. Zu D, Bao Q, He H, Zhong Y, Deng M, Hu Y, Zhang C, Liang C, Huang Y, Liu H, Li X, He Y, Luo G, Wu W, Guan F, Xu S, Liu M, Bacolla A, Jing J, Du Y, Tainer JA, Shi Y, Ye Z, Cheng X
Rational Design of CDK12/13 and BRD4 Molecular Glue Degraders.
1. Angew Chem Int Ed Engl - published September 1, 2025
2. Zhuang Z, Byun WS, Kozicka Z, Donovan KA, Dwyer BG, Thornhill AM, Jones HM, Jiang Z, Zhu X, Fischer ES, Thomä NH, Gray NS
Mutation-induced filaments of folded proteins are inert and non-toxic in a cellular system.
1. Mol Syst Biol - published September 1, 2025
2. Levin T, Garcia-Seisdedos H, Lobov A, Wojtynek M, Alexandrov A, Jona G, Levi D, Medalia O, Levy ED
Crosslinking by ZapD drives the assembly of short FtsZ filaments into toroidal structures in solution.
1. Elife - published September 1, 2025
2. Merino-Salomón A, Scheneider J, Babl L, Krohn JH, Sobrinos-Sanguino M, Schaefer T, Luque-Ortega JR, Alfonso C, Jiménez M, Jasnin M, Schwille P, Rivas G
Structural insights into IMP2 dimerization and RNA binding.
1. J Struct Biol - published September 1, 2025
2. Zorc SA, Munoz-Tello P, O'Leary T, Yu X, Karadi Giridhar MN, Hondros AD, Hansel-Harris A, Forli S, Griffin PR, Kojetin DJ, Roy RN, Janiszewska M
From Pores to Rupture: Structural Basis and Regulation of Lytic Cell Death by Gasdermins and NINJ1.
1. J Biol Chem - published September 1, 2025
2. Wang C, Dreyer B, Teran E, Ruan J
Initial leads to combat streptogramin resistance generated from X-ray fragment screening against VatD.
1. Structure - published September 1, 2025
2. Asthana P, Lee S, MacDonald CM, Seiple IB, Fraser JS
Perfluorooctanoic acid, perfluorobutanoic acid, and undecafluoro-2-methyl-3-oxahexanoic acid disrupt neurotransmitter release and cholinesterase activity.
1. Chemosphere - published September 1, 2025
2. Obiako PC, Taylor BA, Clinger JA, Sayes CM
Environmental and genetic risk factors of depression converge on neuronal dysfunction driven by changes in cholesterol homeostasis.
1. Dev Cell - published September 1, 2025
2. Oberst P, Xu N, Munguba H, Zhang C, Zhong A, Zhou T, Liston C, Levitz J, Studer L
Treatment of a severe vascular disease using a bespoke CRISPR-Cas9 base editor in mice.
1. Nat Biomed Eng - published September 1, 2025
2. Alves CRR, Das S, Krishnan V, Ha LL, Fox LR, Stutzman HE, Shamber CE, Kalailingam P, McCarthy S, Lino Cardenas CL, Fong CE, Imai T, Mitra S, Yun S, Wood RK, Benning FMC, Roh K, Lawton J, Kim N, Silverstein RA, Ferreira da Silva J, de la Cruz D, Richa R, Xie J, Gray-Edwards HL, Malhotra R, Chung DY, Chao LH, Tsai SQ, Maguire CA, Lindsay ME, Kleinstiver BP, Musolino PL
Cage Amine Superbases: Synthesis and Studies of Nona(ethylene)Hexamine and Dodeka(ethylene)Octamine.
1. Chemistry - published September 1, 2025
2. Tan KV, Duong DQ, White KF, Smith BJ, Barnard PJ
α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation.
1. Mol Cell - published September 1, 2025
2. Sitron CS, Trinkaus VA, Galesic A, Garhammer M, Yuste-Checa P, Dransfeld U, Feigenbutz D, Zhang J, Ivashko L, Dudanova I, Harper JW, Hartl FU
The Lasker~Koshland Special Achievement Award in Medical Science awarded to Lucy Shapiro.
1. Proc Natl Acad Sci U S A - published September 1, 2025
2. Vosshall LB
Stabilizing effect of amino acids on protein and colloidal dispersions.
1. Nature - published September 1, 2025
2. Mao T, Xu X, Winkler PM, Siri C, Poliukhina E, Silva PJ, Xu N, Hu Y, Al Zahabi K, La Polla R, Luo Z, Ong Q, Alexander-Katz A, Stellacci F
Functional, immunogenetic, and structural convergence in influenza immunity between humans and macaques.
1. Sci Transl Med - published September 1, 2025
2. Sangesland M, Li N, Tsybovsky Y, Rodgers MD, Han J, Rodriguez AJ, Ferguson JA, Henry AR, Smith SC, Roberts-Torres J, Gillespie RA, Liu C, Merriam JS, Stephens T, Williams C, Walker E, Corcoran M, Ravichandran M, Creanga A, Andrews SF, Pierson TC, Karlsson Hedestam GB, Schramm CA, Reed DS, Douek DC, Zhou T, Ward AB, Kanekiyo M
Biliary Tract Cancers, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology.
1. J Natl Compr Canc Netw - published September 1, 2025
2. Benson AB 3rd, D'Angelica MI, Abrams T, Ahmed A, Akce M, Anaya DA, Anders R, Are C, Aye L, Bachini M, Baker M, Binder D, Brown DB, Burgoyne A, Castellanos J, Cloyd J, Cullinan D, Franses J, Glazer ES, Harris W, Iyer R, Jennings L, Kelley RK, Khan S, Levine M, Melstrom L, Palta M, Raman S, Ronnekleiv-Kelly S, Sahai V, Stein S, Stephans K, Thanikachalam K, Turk A, Vauthey JN, Venook AP, Yano M, Yopp A, Zhao K, Schonfeld R, Hochstetler C
The aflatoxin B(1)-induced formamidopyrimidine adduct is repaired by transcription-coupled nucleotide excision repair in human cells.
1. NAR Cancer - published September 1, 2025
2. Laverty DJ, Tomar R, Erlich S, Stone MP, Nagel ZD
Female membrane proteins regulate postmating ovulation in Drosophila melanogaster by ovulin-dependent and -independent pathways.
1. Proc Natl Acad Sci U S A - published September 1, 2025
2. Yang M, White MA, Findlay GD, Vignogna RC, Apger-McGlaughon J, Clark NL, Choi JY, Fromme JC, Wolfner MF
Pharmacologic interrogation of USP28 cellular function in p53 signaling.
1. Cell Chem Biol - published September 1, 2025
2. Bratt AS, Kilgas S, Tarazona Guzman MI, Magin RS, Jaen Maisonet I, Starnbach CA, Teh WP, Varca AC, Hu B, Tarazona Guzman E, Seo HS, Dhe-Paganon S, Girardi NM, Adelmant G, Marto JA, Chowdhury D, Buhrlage SJ
DeepSCEM: A User-Friendly Solution for Deep Learning-Based Image Segmentation in Cellular Electron Microscopy.
1. Biol Cell - published September 1, 2025
2. Meyer C, Hanss V, Baudrier E, Naegel B, Schultz P
Recent synthetic methodology advancements towards all-carbon quaternary center formation and applications.
1. Tetrahedron - published September 1, 2025
2. Ling T, Garfias JM, Lawson SL, Rivas F
Nodal modulator (NOMO) is a force-bearing transmembrane protein required for muscle differentiation.
1. J Cell Biol - published September 1, 2025
2. Naughton BS, Devarkar SC, Todorow V, Mallik S, Oxendine S, Junnarkar S, Ren Y, Berro J, Kirstein J, Xiong Y, Schlieker C
Computational structure prediction of lanthipeptides with NMR data reveals underappreciated peptide flexibility.
1. Protein Sci - published September 1, 2025
2. Tydings CW, Meiler J, Walker AS
Global Longitudinal Strain: A Potential Noninvasive Tool for Early Detection of Radiation-Induced Cardiac Dysfunction in Patients With Lung Cancer Receiving Thoracic Radiation Therapy.
1. Int J Radiat Oncol Biol Phys - published September 1, 2025
2. Montalvo SK, Lue B, Kakadiaris E, Ahn C, Zhang-Velten E, Aliru M, Lu W, Westover KD, Iyengar P, Timmerman RD, Zaha VG, Vallabhaneni S, Zhang K, Chandra A, Alluri PG
Mechano-chemical encapsulation of gemcitabine hydrochloride on metal-organic framework, preparation of shaped pellets, delayed drug release, and time-dependent toxicity to PANC-1 cancer cells.
1. J Drug Deliv Sci Technol - published September 1, 2025
2. Umar S, Catazaro J, Wachira J, Samokhvalov A
AlphaFold model quality self-assessment improvement via deep graph learning.
1. Protein Sci - published September 1, 2025
2. Verburgt J, Zhang Z, Kihara D
Cryo-EM structures of CRAF/MEK1/14-3-3 complexes in autoinhibited and open-monomer states reveal features of RAF regulation.
1. Nat Commun - published September 1, 2025
2. Jang DM, Boxer K, Ha BH, Tkacik E, Levitz T, Rawson S, Metivier RJ, Schmoker A, Jeon H, Eck MJ