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100 Member Publications for June

Previous Month

Multi-omics analysis of flavor differences in pectoral muscles between Wuqin 10 duck and Cherry valley duck.
1. Front Mol Biosci - published June 16, 2025
2. Gong P, Ye S, Chen X, Wang L, Qian Y, Zhai M, Yang Y
Characterizing nitrogen cycling microorganisms and genes in sediments of the Three Gorges Reservoir.
1. PLoS One - published June 10, 2025
2. Han C, Chen Z, Xiao Y, Yang T, Shi H, Cao H, Yang W, Gong P
Small molecule disruption of RARα/NCoR1 interaction inhibits chaperone-mediated autophagy in cancer.
1. EMBO Mol Med - published June 9, 2025
2. McCabe M, Bhattacharyya R, Sereda R, Santiago-Fernández O, Khawaja RR, Diaz A, Lindenau K, Ozturk DG, Garner TP, Sidoli S, Cuervo AM, Gavathiotis E
Development of Mutant M(3) Muscarinic Receptors Biased for G Protein Activation or Recruitment of β-Arrestins.
1. Biochemistry - published June 9, 2025
2. Meister J, Wanka L, Perry-Hauser NA, Liu L, Iverson TM, Gurevich VV, Beck-Sickinger AG, Kruse AC, Wess J
Data-Independent Acquisition Parallel Accumulation-Serial Fragmentation (diaPASEF) Analysis of the Separated Zebrafish Lens Improves Identifications.
1. J Am Soc Mass Spectrom - published June 9, 2025
2. Zelle SR, McDonald WH, Rose KL, Mchaourab HS, Schey KL
Cell-based high-content approach for SARS-CoV-2 neutralization identifies unique monoclonal antibodies and PI3K pathway inhibitors.
1. Front Cell Dev Biol - published June 9, 2025
2. Cabel CR, Guzman BA, Alizadeh E, Li S, Holberg C, Wichaidit C, Cusanovich DA, Paek AL, Thatcher GRJ, Van Doorslaer K, Nargi RS, Sutton RE, Suryadevara N, Crowe JE Jr, Carnahan RH, Campos SK, Thorne CA
The Flagellin-Specific Chaperone FliS of Borrelia burgdorferi Controls the Cytoplasmic Pool of Flagellins at the Level of Translation Initiation, Secretion, and Proteolysis.
1. Mol Microbiol - published June 9, 2025
2. Sze CW, Zhang K, Lynch MJ, Guo W, Liu J, Crane BR, Li C
Selective Flotation of Rutile from Chlorite Using a Combined CMC and SSF Depressant in a Benzohydroxamic Acid Collector System.
1. Langmuir - published June 9, 2025
2. Ren L, Gong P, Huang Y, Han G, Bao S, Zhang Y, Nguyen AV
Structural determinants of PAR1 cleavage by activated protein C.
1. J Thromb Haemost - published June 9, 2025
2. Stojanovski BM, Di Cera E
Probe design for high sensitivity proton-detected solid-state NMR.
1. J Magn Reson - published June 9, 2025
2. Borcik CG, Price LE, Heinrich JP, Stringer JA, Rienstra CM
A multi-step immune-competent genetic mouse model reveals phenotypic plasticity in uveal melanoma.
1. bioRxiv - published June 7, 2025
2. Xu X, Liu X, Dollar JJ, Liu X, Jasani N, Posorske B, Sriramareddy SN, Jarajapu V, Kuznetsoff JN, Sinard J, Bennett RL, Licht JD, Smalley KSM, Harbour JW, Yu X, Karreth FA
The SH protein of mumps virus is a druggable pentameric viroporin.
1. Sci Adv - published June 6, 2025
2. Devantier K, Toft-Bertelsen TL, Prestel A, Kjær VMS, Sahin C, Giulini M, Louka S, Spiess K, Manandhar A, Qvortrup K, Ulven T, Bentzen BH, Bonvin AM, MacAulay N, Kragelund BB, Rosenkilde MM
Strategy to overcome a nirmatrelvir resistance mechanism in the SARS-CoV-2 nsp5 protease.
1. Sci Adv - published June 6, 2025
2. Neilsen G, Lan S, Slack RL, Lorson ZC, Emanuelli Castaner A, Lee R, Edwards KG, Zhang H, Lee J, Cantara WA, Cilento ME, Zhang H, De R, Amblard F, Tedbury PR, Kirby KA, Schinazi RF, Sarafianos SG
Multiomics analysis unveils key biomarkers during dynamic progress of IAV infection in mice.
1. Front Immunol - published June 6, 2025
2. Lei H, Xu Y, Zhang H, Zhang B, Luo W, Liu X, Zhang H, Yang J, Wen W, Wang P, Xu S
Identification and Characterization of the Biosynthesis of the Hybrid NRPS-NIS Siderophore Nocardichelin.
1. ACS Chem Biol - published June 6, 2025
2. Fisk MB, Barrera Ramirez J, Merrick CE, Wencewicz TA, Gulick AM
pH Controlled Activation and Stabilization of Enzymes Using Responsive Polymer-Bioconjugates.
1. Biomacromolecules - published June 6, 2025
2. Rahman MS, Chandrarathne B, Bender K, Hinkle J, Page RC, Konkolewicz D
A highly sensitive protein-RNA cross-linking mass spectrometry workflow with enhanced structural modeling potential.
1. Nucleic Acids Res - published June 6, 2025
2. Sarnowski CP, Knörlein A, de Vries T, Götze M, Beusch I, Aebersold R, Allain FH, Hall J, Leitner A
The Fetal-to-Adult Hemoglobin Switch - Mechanism and Therapy.
1. N Engl J Med - published June 5, 2025
2. Orkin SH
GPR45 modulates Gα(s) at primary cilia of the paraventricular hypothalamus to control food intake.
1. Science - published June 5, 2025
2. Xun Y, Jiang Y, Xu B, Tang M, Ludwig S, Nakamura K, Mukhopadhyay S, Liu C, Beutler B, Zhang Z
Pan-H7 influenza human antibody virus neutralization depends on avidity and steric hindrance.
1. JCI Insight - published June 5, 2025
2. Gilchuk IM, Dong J, Irving RP, Buchman CD, Armstrong E, Turner HL, Li S, Ward AB, Carnahan RH, Crowe JE Jr
Mechanism of human α3β GlyR regulation by intracellular M3/M4 loop phosphorylation and 2,6-di-tert-butylphenol interaction.
1. Nat Commun - published June 5, 2025
2. Liu X, Krezel M, Wang W
Unravelling CYP4V2: Clinical Features, Genetic Insights, Pathogenic Mechanisms and Therapeutic Strategies in Bietti Crystalline Corneoretinal Dystrophy.
1. Prog Retin Eye Res - published June 5, 2025
2. Jia R, Chen S, Li W, Zhang J, Qu B, Qiao J, Meng X, Yu S, Liu X, Xu B, Chen T, Shen X, Sun W, Dou H, Mahajan VB, Zhang Q, Yang L
General Maintenance and Reactivation of iSLK Cell Lines.
1. Bio Protoc - published June 5, 2025
2. Calderón-Zavala AC, Mendez AS, Heldwein EE
Redefining the role of the EryM acetyltransferase in natural product biosynthetic pathways.
1. Structure - published June 5, 2025
2. Li Y, Liu X, Harris NR, Roberts JR, Valdivia EM, Ji X, Smith JL
Tetrahydropyrido[4,3-d]pyrimidines as a new active scaffold for human topoisomerase II inhibitors.
1. Sci Rep - published June 4, 2025
2. Brindani N, La Serra MA, Ortega JA, Arencibia JM, Nigro M, Bertozzi SM, Armirotti A, Borgogno M, Sissi C, De Vivo M
Characterization of Hepatotropic Small Molecule Inhibitors of Hypoxia Inducible Factor Prolyl Hydroxylase in the Prevention of Oxygen-Induced Retinopathy.
1. J Med Chem - published June 4, 2025
2. Campla C, Hoppe G, Yu M, Woda J, Peachey NS, Josyula VP, Stauffer SR, Sears JE
Antimicrobial Activity of Brilacidin against E. coli.
1. ACS Infect Dis - published June 3, 2025
2. Wilhelm MJ, Sharifian Gh M, Mensa B, Howell GL, DeGrado WF, Dai HL
Substrate recognition and allosteric regulation of synaptic vesicle glutamate transporter VGLUT2.
1. Nat Struct Mol Biol - published June 3, 2025
2. Li F, Eriksen J, Oses-Prieto JA, Gomez YK, Xu H, Hareendranath S, Das P, Finer-Moore J, Nguyen P, Bowen A, Nelson A, Burlingame A, Grabe M, Stroud RM, Edwards RH
Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraints.
1. J Biol Chem - published June 3, 2025
2. Alexander P, Chan AH, Rabara D, Swain M, Larsen EK, Dyba M, Chertov O, Ashraf M, Champagne A, Lin K, Maciag A, Gillette WK, Nissley DV, McCormick F, Simanshu DK, Stephen AG
Neuroendocrine cells orchestrate regeneration through Desert hedgehog signaling.
1. Cell - published June 3, 2025
2. Kong W, Lu WJ, Dubey M, Suryawanshi RK, Vijayakumar S, Jeong Y, Gombar S, Diehn M, Shin K, Ott M, Chien YH, Sarin KY, Desai TJ, Beachy PA
A histidine switch regulates pH-dependent filament formation by the caspase-9 CARD.
1. bioRxiv - published June 3, 2025
2. Rawal S, Kolarić Ð, Bohn S, Kolb D, Pavkov-Keller T, Pritišanac I, Madl T, Desfosses A, Reid Alderson T
An intrinsically disordered region of histone demethylase KDM5A activates catalysis through interactions with the nucleosomal acidic patch and DNA.
1. J Mol Biol - published June 2, 2025
2. Palla AM, Lin CC, Trnka MJ, Leao EM, Petronikolou N, Burlingame AL, McGinty RK, Fujimori DG
Protein-based Radiopharmaceuticals that target fibroblast activation protein alpha: a review of current progress.
1. EJNMMI Radiopharm Chem - published June 2, 2025
2. Homedan A, Pandya DN, Schnicker NJ, Wadas TJ
Structures of vertebrate R2 retrotransposon complexes during target-primed reverse transcription and after second-strand nicking.
1. Sci Adv - published June 2, 2025
2. Thawani A, Rodríguez-Vargas A, Van Treeck B, Hassan NT, Adelson DL, Nogales E, Collins K
Monoclonal antibodies targeting the FimH adhesin protect against uropathogenic E. coli UTI.
1. Sci Adv - published June 2, 2025
2. Lopatto EDB, Santiago-Borges JM, Sanick DA, Malladi SK, Azimzadeh PN, Timm MW, Fox IF, Schmitz AJ, Turner JS, Sayed Ahmed SM, Ortinau L, Gualberto NC, Pinkner JS, Dodson KW, Ellebedy AH, Kau AL, Hultgren SJ
The postsynaptic density in excitatory synapses is composed of clustered, heterogeneous nanoblocks.
1. J Cell Biol - published June 2, 2025
2. Sun R, Allen JP, Mao Z, Wilson L, Haider M, Alten B, Zhou Z, Wang X, Zhou Q
Importin-9 and a TPR domain protein MpH drive periodic patterning of ciliary arrays in Tetrahymena.
1. J Cell Biol - published June 2, 2025
2. Deraniyagala AS, Maier W, Parra M, Nanista E, Sowunmi DO, Hassan M, Chasen N, Sharma S, Lechtreck KF, Cole ES, Bernardes N, Chook YM, Gaertig J
Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design.
1. J Exp Med - published June 2, 2025
2. Groen K, Kuratli R, Enkelmann J, Fernbach S, Wendel-Garcia PD, Staiger WI, Lejeune M, Sauras-Colón E, Roche-Campo F, Filippidis P, Rauch A, Swiss HIV Cohort Study, Trkola A, Günthard HF, Kouyos RD, Brugger SD, Hale BG
Biochemistry of Heat Shock Proteins From Human Intracellular Protozoan Parasites as Diagnostic and Therapeutic Biomarkers.
1. Biochemistry - published June 2, 2025
2. Chakafana G, Zininga T
A deoxynucleoside triphosphate triphosphohydrolase promotes cell cycle progression in Caulobacter crescentus.
1. J Bacteriol - published June 2, 2025
2. Hellenbrand CN, Stevenson DM, Gromek KA, Amador-Noguez D, Hershey DM
Transitions in the proteome and phospho-proteome during Xenopus laevis development.
1. Dev Biol - published June 2, 2025
2. Van Itallie E, Sonnett M, Kalocsay M, Wühr M, Peshkin L, Kirschner MW
Lignin Removal in Subcellular Location of Poplar Cell Wall During Pretreatment Significantly Impacts Cellulose Digestibility.
1. ACS Sustain Chem Eng - published June 2, 2025
2. Zhang J, Kang L, Shen W, Collings C, Gong H, Vander Meulen K, Fox BG, Gilcher E, Dumesic JA, Ding SY
Structural and functional basis of mechanosensitive TMEM63 channelopathies.
1. Neuron - published June 2, 2025
2. Zheng W, Lowry AJ, Smith HE, Xie J, Rawson S, Wang C, Ou J, Sotomayor M, Fu TM, Yang H, Holt JR
A distinct LHCI arrangement is recruited to photosystem I in Fe-starved green algae.
1. Proc Natl Acad Sci U S A - published June 2, 2025
2. Liu HW, Khera R, Grob P, Gallaher SD, Purvine SO, Nicora CD, Lipton MS, Niyogi KK, Nogales E, Iwai M, Merchant SS
HIV-1 binds dynein directly to hijack microtubule transport machinery.
1. Sci Adv - published June 2, 2025
2. Badieyan S, Lichon D, Keceli SK, Andreas MP, Gillies JP, Peng W, Shi J, DeSantis ME, Aiken CR, Böcking T, Giessen TW, Campbell EM, Cianfrocco MA
Molecular features defining the efficiency of bioPROTACs.
1. Commun Biol - published June 2, 2025
2. Winkelvoß D, Vukovic D, Hänny AC, Riermeier L, Udovcic A, Kolibius J, Honegger A, Mittl PRE, Michel E, Hansen S, Plückthun A
5hmC enhances PARP trapping and restores PARP inhibitor sensitivity in chemoresistant BRCA1/2-deficient cells.
1. J Biol Chem - published June 1, 2025
2. Kharat SS, Mishra AP, Sengodan SK, Dierman D, Fox SD, Chazin WJ, Sharan SK
Combination of in vivo and in vitro phosphoproteomics determines the PP2A target repertoire on proteome scale.
1. Cell Rep Methods - published June 1, 2025
2. Brunner M, Hu Z, Elkhaligy H, Lampo G, Roubaty C, Vionnet C, Sankar DS, McIlwain SJ, Kaeser-Pebernard S, Xing Y, Dengjel J
Inhibiting Lipopolysaccharide Biogenesis: The More You Know the Further You Go.
1. Annu Rev Biochem - published June 1, 2025
2. Moffatt CB, Plaman BA, Rowe SJ, Caruso A, Early SA, Ruiz N, Kahne D
Ethyl Acetate Fraction of Zanthoxylum bungeanum Ameliorates Cognitive Deficit by Facilitating the PHGDH-Dependent Astrocyte-Neuron Serine Shuttle in Aging Mice.
1. J Agric Food Chem - published June 1, 2025
2. Zhao M, Zeng L, Zhou Y, Yang C, Sheng R, Liu X, Wen W, Yang S, Zhang S, Xu S
In Defense of Biochemistry: Studies of Transcriptional Regulation.
1. J Mol Biol - published June 1, 2025
2. Kornberg RD, Feklistov A
AI-based quality assessment methods for protein structure models from cryo-EM.
1. Curr Res Struct Biol - published June 1, 2025
2. Zhu H, Terashi G, Farheen F, Nakamura T, Kihara D
Enhanced genotype-phenotype analysis using multimodal adaptive optics and 3D protein structure in Bietti Crystalline Dystrophy.
1. Am J Ophthalmol Case Rep - published June 1, 2025
2. Kumar A, Sun YJ, Rasmussen DK, Hargrave A, Phillips C, Vu JT, Costa MGS, Leung LB, Yu C, Dubra A, Mahajan VB
Corrigendum to "STING guides the STX17-SNAP29-VAMP8 complex assembly to control autophagy" [Cell Insight 3 (2024) 100147].
1. Cell Insight - published June 1, 2025
2. Song X, Xi Y, Dai M, Li T, Du S, Zhu Y, Li M, Li Y, Liu S, Ding X, Yao X, Lai Y, Liu X
Lysine acetylation modulates s-OPA1 GTPase activity and oligomerization in mitochondrial membrane remodeling.
1. Protein Sci - published June 1, 2025
2. Jabbar J, Afroze B, Ling NXY, Oakhill JS, Rouiller I
Structure and organization of full-length epidermal growth factor receptor in extracellular vesicles by cryo-electron tomography.
1. Proc Natl Acad Sci U S A - published June 1, 2025
2. Gonzalez-Magaldi M, Gullapalli A, Papoulas O, Liu C, Leung AY, Guo L, Brilot AF, Marcotte EM, Ke Z, Leahy DJ
CACNA1D is a circadian gene and causes familial advanced sleep phase.
1. Proc Natl Acad Sci U S A - published June 1, 2025
2. Webb JM, Abderemane-Ali F, Ashbrook L, Ma M, Nibber N, Zou X, Yamazaki M, Wohler E, Sobreira N, Minor DL Jr, Fu YH, Ptáček LJ
Assembly and activation of the death-inducing signaling complex.
1. Proc Natl Acad Sci U S A - published June 1, 2025
2. Fosuah E, Shen Z, Xie J, Wang C, Lin Q, Fu TM
Solution mapping of MHC-I:TCR interactions using a minimalistic protein system.
1. Proc Natl Acad Sci U S A - published June 1, 2025
2. Woodward CH, Chaudhuri A, Chen XT, White WL, Garcia KC, Baker D, Sgourakis NG
Protecting bacteriophages under UV irradiation with brilliant blue FCF for targeted bacterial control.
1. Biofilm - published June 1, 2025
2. Wdowiak M, Magiera A, Tomczyńska M, Adamkiewicz W, Stellacci F, Paczesny J
Modulation of SARS-CoV-2 spike binding to ACE2 through conformational selection.
1. Nat Nanotechnol - published June 1, 2025
2. Saha P, Fernandez I, Sumbul F, Valotteau C, Kostrz D, Meola A, Baquero E, Sharma A, Portman JR, Stransky F, Boudier T, Guardado-Calvo P, Gosse C, Strick T, Rey FA, Rico F
Searching for Synthetic Opioid Rescue Agents. 2: Identification of an Ultra-Potent Synthetic Opioid Rescue Agent.
1. J Med Chem - published June 1, 2025
2. Martin J, Onyameh E, Luo D, Powell JW, Trivedi RR, Woloshin EJ, Zhang Y, Shaykin JD, Denehy ED, Alsum AR, Prantzalos E, Jiang Q, Che T, Alilain WJ, Turner JR, Bardo MT, Prisinzano TE
RosettaAMRLD: A Reaction-Driven Approach for Structure-Based Drug Design from Combinatorial Libraries with Monte Carlo Metropolis Algorithms.
1. J Chem Inf Model - published June 1, 2025
2. Tang Y, Moretti R, Meiler J
Nonstabilized SARS-CoV-2 spike mRNA vaccination induces broadly neutralizing antibodies in nonhuman primates.
1. Sci Transl Med - published June 1, 2025
2. Malewana RD, Stalls V, May A, Lu X, Martinez DR, Schäfer A, Li D, Barr M, Sutherland LL, Lee E, Parks R, Beck WE, Newman A, Bock KW, Minai M, Nagata BM, DeMarco CT, Denny TN, Oguin TH 3rd, Rountree W, Wang Y, Mansouri K, Edwards RJ, Smith L, Sempowski GD, Eaton A, Muramatsu H, Henderson R, Tam Y, Barbosa C, Tang J, Cain DW, Santra S, Moore IN, Andersen H, Lewis MG, Golding H, Seder R, Khurana S, Montefiori DC, Pardi N, Weissman D, Baric RS, Acharya P, Haynes BF, Saunders KO
Global siRNA screen identifies human host factors critical for SARS-CoV-2 replication and late stages of infection.
1. PLoS Biol - published June 1, 2025
2. Yin X, Pu Y, Yuan S, Pache L, Churas C, Weston S, Riva L, Simons LM, Cisneros WJ, Clausen T, Biddle G, Doss-Gollin S, Deming M, De Jesus PD, Kim HN, Fuentes D, Whitelock JM, Esko JD, Lord MS, Mena I, García-Sastre A, Hultquist JF, Frieman MB, Ideker T, Pratt D, Martin-Sancho L, Chanda SK
Flagellar switch inverted repeats impact heterogeneity in flagellar gene expression and thus C. difficile RT027/MLST1 virulence.
1. Cell Rep - published June 1, 2025
2. Nhu NTQ, Lin H, Pigli Y, Sia JK, Kuhn P, Ruppel H, Snitkin ES, Young VB, Kamboj M, Pamer EG, Rice PA, Shen A, Dong Q
BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction.
1. Science - published June 1, 2025
2. Simanshu DK, Xu R, Stice JP, Czyzyk DJ, Feng S, Denson JP, Riegler E, Yang Y, Zhang C, Donovan S, Smith BP, Abreu-Blanco M, Chen M, Feng C, Fu L, Rabara D, Young LC, Dyba M, Yan W, Lin K, Ghorbanpoorvalukolaie S, Larsen EK, Malik W, Champagne A, Parker K, Ju JH, Jeknic S, Esposito D, Turner DM, Lightstone FC, Wang B, Wehn PM, Wang K, Stephen AG, Maciag AE, Hata AN, Sinkevicius KW, Nissley DV, Wallace EM, McCormick F, Beltran PJ
SARS-CoV-2 nsp15 enhances viral virulence by subverting host antiviral defenses.
1. Proc Natl Acad Sci U S A - published June 1, 2025
2. Caobi A, Su CM, Beusch CM, Kenney D, Darling TL, Feng S, Semaan M, Wacquiez A, Sanders NL, Tully ES, Chen DY, Evdokimova M, Ding Z, Jones D, Alysandratos KD, Mizgerd JP, Kirchdoerfer RN, Kotton DN, Douam F, Crossland NA, Boon ACM, Gordon DE, Baker SC, Saeed M
Disassembly activates Retron-Septu for antiphage defense.
1. Science - published June 1, 2025
2. Wang C, Rish AD, Armbruster EG, Xie J, Loveland AB, Shen Z, Gu B, Korostelev AA, Pogliano J, Fu TM
Priming or Boosting P. falciparum Transmission Blocking Responses with Recombinant Vaccines or Gametocyte Extract.
1. J Infect Dis - published June 1, 2025
2. Song Y, Deng B, Long CA, Li Q, Diakite M, Huang WC, Zhou S, Luo Y, Ivanochko D, MacGill RS, Julien JP, Miura K, Lovell J
Structural insights into the activation and inhibition of the ADAM17-iRhom2 complex.
1. Proc Natl Acad Sci U S A - published June 1, 2025
2. Maciag JJ, Slone CE, Alnajjar HF, Rich MF, Guion B, Ifergan I, Blobel CP, Seegar TCM
Switchable client specificity in a dual functional chaperone coordinates light-harvesting complex biogenesis.
1. Sci Adv - published June 1, 2025
2. Siegel AR, Kroon G, Zhao C, Wang P, Wright PE, Shan SO
Design of SARS-CoV-2 RBD immunogens to focus immune responses toward conserved coronavirus epitopes.
1. J Virol - published June 1, 2025
2. Harris C, Kapingidza AB, San JE, Christopher J, Gavitt T, Rhodes B, Janowska K, O'Donnell C, Lindenberger J, Huang X, Sammour S, Berry M, Barr M, Parks R, Newman A, Overton M, Oguin T 3rd, Acharya P, Haynes BF, Saunders KO, Wiehe K, Azoitei ML
Clinicopathologic Features of Untreated Colorectal Cancer with Acellular Mucin-Only Lymph Nodes.
1. Mod Pathol - published June 1, 2025
2. Luo W, Hu S, Riahi IR, Wang HL, Shaker N, Abukhiran I, Wang T, Polydorides AD, Akinsanya A, González IA, Hagen C, Graham RP, Lisovsky M, Longacre TA, Challa B, Chen W, Harter D, Beech C, Najibi M, Cao W, Lee M, Lagana SM, Liao X, Setia N, Westbrook LM, Chandan VS, Choi WT, Ding X, Gonzalez RS, Gopal P, Lee H, Navale P, Liu X, Panarelli NC, Yang Z, Drage MG, Song Z, Li F, Nagtegaal ID, Zhang X
Nanobodies targeting EGFR provide insight into conformations stabilized by glioblastoma mutations.
1. J Biol Chem - published June 1, 2025
2. Watson SM, Harvey EP, Pishesha N, Ploegh HL, Springer TA
Mutation of an active site-adjacent residue in VIM indirectly dictates interactions with and blunts inhibition by D-captopril.
1. J Inorg Biochem - published June 1, 2025
2. Silwal SB, Wamsley B, Wang Z, Gung BW, Nix JC, Page RC
Transient glycan shield reduction induces CD4-binding site broadly neutralizing antibodies in SHIV-infected macaques.
1. Cell Rep - published June 1, 2025
2. Morris DJ, Gorman J, Zhou T, Lora J, Connell AJ, Li H, Liu W, Roark RS, Campion MS, Carey JW, Habib R, Li Y, Martella CL, Park Y, Singh A, Sowers KJ, Teng IT, Wang S, Chohan N, Ding W, Lauer C, Lewis E, Mason RD, Rando JM, Peyton L, Schramm CA, Wagh K, Korber B, Seaman MS, Douek DC, Haynes BF, Kulp DW, Roederer M, Hahn BH, Kwong PD, Shaw GM
An ABCB11 variant registry and novel knockin mouse model of PFIC2 based on the clinically relevant ABCB11 E297G variant.
1. J Lipid Res - published June 1, 2025
2. Bell EL, Truong JK, Jo Y, Kolpak A, Chunn L, Syverud N, Mahinic M, Durrant JR, Hoch E, Reddy B, Stoiber P, Miller JP, Ren Y, Moore J, Hughes RO, Garfield AS
A nucleotide-independent, pan-RAS-targeted DARPin elicits anti-tumor activity in a multimodal manner.
1. Mol Oncol - published June 1, 2025
2. Kapp JN, Verdurmen WPR, Schaefer JV, Kopra K, Nagy-Davidescu G, Richard E, Nokin MJ, Ernst P, Tamaskovic R, Schwill M, Degen R, Scholl C, Santamaria D, Plückthun A
Neuronal ALKAL2 and its ALK receptor contribute to the development of colitis-associated colorectal cancer.
1. Proc Natl Acad Sci U S A - published June 1, 2025
2. Delanne-Cuménal M, Defaye M, Delanne-Cuménal A, Ahmed M, Ho V, Abdullah NS, Alhassoun M, Svendsen K, Mager L, Schlessinger J, Hirota S, Altier C
Molecular basis for Gβγ-SNARE mediated inhibition of synaptic vesicle fusion.
1. J Biol Chem - published June 1, 2025
2. Eitel AR, Mueller BK, Kaya AI, Young M, Cassada JB, Bell EW, Schnitkey L, Zurawski Z, Yim YY, Zhou Q, Meiler J, Hamm HE
Characterizing protein sequence determinants of nuclear condensates by high-throughput pooled imaging with CondenSeq.
1. Nat Methods - published June 1, 2025
2. Kappel K, Strebinger D, Edmonds KK, Chau-Duy-Tam Vo S, Vockley CM, Biswas T, Farhi SL, Macrae R, Zhang F, Regev A
Enhancing Selectivity and Potency of S(N)Ar Covalent Inhibitors of NADPH Oxidase Enzymes.
1. J Med Chem - published June 1, 2025
2. Ogboo BC, Patel KB, Massari M, Marchese S, Reis J, Joyce EJ, Lin MJ, Rabb JD, Abidakun OA, Lin Q, van der Vliet A, Mattevi A, Heppner DE
The zinc metalloprotein MigC impacts cell wall biogenesis through interactions with an essential Mur ligase in Acinetobacter baumannii.
1. PLoS Pathog - published June 1, 2025
2. Critchlow JM, Rocchio JS, McKell MC, Campbell CJ, Barraza JP, Krystofiak ES, Green ER, Akizuki T, Chazin WJ, VanNieuwenhze MS, Stemmler TL, Giedroc DP, Skaar EP
Gestational hypertension increases risk of seizures in children and mice.
1. J Clin Invest - published June 1, 2025
2. Xue B, Gumusoglu SB, Tiarks G, Todd BP, Wong A, Santillan DA, Kuo CC, Chiang HY, Ravindranath R, Wang SY, Mahajan VB, Johnson AK, Davis HA, Ferguson P, Newell EA, Santillan MK, Misurac JM, Bassuk AG
Dendritic cell targeting in lymph nodes with modular adapters boosts HAdV5 and HC-HAdV5 tumor vaccination by co-secretion of IL-2v and IL-21.
1. Mol Ther Oncol - published June 1, 2025
2. Weiss F, Kolibius J, Freitag PC, Gantenbein F, Kipar A, Plückthun A
Anti-Müllerian hormone binds heat shock protein glucose-regulated protein 78 in human follicular fluid.
1. J Assist Reprod Genet - published June 1, 2025
2. Sacha CR, Nagykery N, Meinsohn MC, Mattos K, Howard JA, Ramadan H, Minis E, Zhang L, Fitz V, Hammer K, Souter IC, Thompson TB, Donahoe PK, Pépin D
Coordinated Residue Motions at the Enzyme-Substrate Interface Promote DNA Translocation in Polymerases.
1. J Am Chem Soc - published June 1, 2025
2. Visigalli A, Trizio E, Bonati L, Vidossich P, Parrinello M, De Vivo M
DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation.
1. Nat Struct Mol Biol - published June 1, 2025
2. Lee C, Eldridge MJG, Gonzalez-Lozano MA, Bresnahan T, Niday Z, Del Camino D, Fu T, Paulo JA, Moran MM, Helaine S, Harper JW
Milestones in the development of Myxococcus xanthus as a model multicellular bacterium.
1. J Bacteriol - published June 1, 2025
2. Kroos L, Wall D, Islam ST, Whitworth DE, Muñoz-Dorado J, Higgs PI, Singer M, Mauriello EM, Treuner-Lange A, Søgaard-Andersen L, Kaimer C, Elías-Arnanz M, Stojković EA, Müller R, Volz C, Velicer GJ, Nan B
Crossover operators for molecular graphs with an application to virtual drug screening.
1. J Cheminform - published June 1, 2025
2. Domschke N, Schmidt BJ, Gatter T, Golnik R, Eisenhuth P, Liessmann F, Meiler J, Stadler PF
Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma.
1. Mol Cell - published June 1, 2025
2. Nardone C, Gao J, Seo HS, Mintseris J, Ort L, Yip MCJ, Negasi M, Besschetnova AK, Kamitaki N, Gygi SP, Dhe-Paganon S, Munshi NC, Fulciniti M, Greenberg ME, Shao S, Elledge SJ, Gu X
Divergence in a eukaryotic transcription factor's co-TF dependence involves multiple intrinsically disordered regions.
1. Nat Commun - published June 1, 2025
2. Snyder LF, O'Brien EM, Zhao J, Liang J, Bruce BJ, Zhang Y, Zhu W, Cassier TH, Schnicker NJ, Zhou X, Gordân R, He BZ
Blocking the functional domain of cancer cell surface TIP1 upregulates Midkine via the β-catenin/Wnt signaling pathway.
1. Cancer Gene Ther - published June 1, 2025
2. Saikia M, Shah HK, Hallahan DE, Singh AK, Kapoor V
A Contemporary View of Mechanosensory Transduction in Auditory Hair Cells.
1. Biophys J - published June 1, 2025
2. Mun M, Holt JR
Multiple transactivation domains of EZH2 bind to the TAZ2 domain of p300 and stimulate acetyltransferase function of p300.
1. Biochem J - published June 1, 2025
2. Becht D, Biswas S, Xu C, Xuan H, Khalil M, Cai L, Musselman C, Liu X, Affar EB, Shi X, Wang G, Kutateladze T
ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism.
1. Nat Struct Mol Biol - published June 1, 2025
2. Rashan EH, Bartlett AK, Khana DB, Zhang J, Jain R, Wade G, Abriata LA, Smith AJ, Baker ZN, Cook T, Caldwell A, Chevalier AR, Forny P, Pfleger BF, Peraro MD, Yuan P, Amador-Noguez D, Simcox JA, Pagliarini DJ
Directed Evolution of a SelB Variant that Does Not Require a Selenocysteine Insertion Sequence Element for Function.
1. ACS Synth Biol - published June 1, 2025
2. Ishida S, Gundlach A, Kosonocky CW, Ellington AD
Hope for OTHERS (Our Tissue Helping Enhance Research & Science): research results from the University of Pittsburgh rapid autopsy program for breast cancer.
1. Breast Cancer Res - published June 1, 2025
2. Chang AC, Balic M, Bartholow T, Bhargava R, Brown DD, Brown L, Brufsky A, Cao Y, Carleton N, Clark AM, Cody M, Ding K, Deible C, Elangovan A, Foldi J, Geisler D, Hodgdon C, Howard N, Li Z, Liu JB, Lopez-Nunez O, Mary DJSJ, McGinn O, Miller L, Mori K, Pecar G, Priedigkeit N, Puhalla S, Rosenzweig MQ, Roy P, Savariau L, Walker S, Waltermire H, Wedn AM, Wells A, Yates ME, Xavier J, Lee AV, Oesterreich S
A first-in-class EGFR-directed KRAS G12V selective inhibitor.
1. Cancer Cell - published June 1, 2025
2. Stanland LJ, Huggins HP, Sahoo SS, Porrello A, Chareddy Y, Azam SH, Perry JL, Pallan PS, Whately K, Edatt L, Green WD, Fleming MC, Im J, Gutierrez-Ford C, Simmons I, Dawoud A, Zhou KI, Jayaprakash V, Sellers RS, Cruz G, Wielgus A, Milner J, Egli M, Bowers AA, Pecot CV