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128 Member Publications for January 2026

Structural Basis for how Sialoglycan-binding Viridans Streptococci Accommodate Ligands that Exceed the Characterized Binding Site.
1. MicroPubl Biol - published January 23, 2026
2. Morrison KM, Martin K, Yu H, Chen X, Iverson TM
Synaptic Cell Adhesion: A Structural Perspective.
1. Adv Neurobiol - published January 22, 2026
2. Bandekar SJ, Kordon SP, Araç D
Recent Structural Insights into the Molecular Architecture of Synapses.
1. Adv Neurobiol - published January 22, 2026
2. Brunger AT, Held RG, Khan YA, Leitz J, Liang J, Wang C, White KI
Visualizing Postsynaptic Density in Excitatory Synapses with Electron Tomography.
1. Adv Neurobiol - published January 22, 2026
2. Sun R, Zhou Q
Insights into the Structure of Intermediate Filaments.
1. Subcell Biochem - published January 20, 2026
2. Eibauer M, Medalia O
The Yeh pilus adhesin is equipped with an α-helical flap motif, which contributes to pectin adherence.
1. Sci Adv - published January 9, 2026
2. Tamadonfar KO, Klein RD, Lopatto EDB, Zimmerman MI, Azimzadeh PN, Sanick DA, Porter JR, Villicana JB, Pinkner JS, Chiang BH, Gualberto NC, Dodson KW, Patnode ML, Birchenough GMH, Bowman GR, Hultgren SJ
Molecular insight into 5' RNA capping with Np(n)Ns by bacterial RNA polymerase.
1. Nat Chem Biol - published January 9, 2026
2. Serianni VM, Škerlová J, Dubánková AK, Škríba A, Šváchová H, Vučková T, Filimoněnko A, Fábry M, Řezáčová P, Kouba T, Cahova H
Butyrophilin 2A2 promotes T cell immunoregulation via CD45 phosphatase activation and protects against murine autoimmune glomerulonephritis and pregnancy loss.
1. Nat Commun - published January 8, 2026
2. Ali S, Berg AH, Yamashita M, Covarrubias AE, Mundell J, Shah PN, Zhang R, Dupont V, Shin BH, Yang S, Katiki M, Murali R, Pisarska MD, Thadhani R, Heeger PS, Jordan SC, Karumanchi SA
Phosphoproteomics Identification of ERK-Dependent Activation of Rps6kb1 in Cardiac Hypertrophy.
1. JCI Insight - published January 8, 2026
2. Li C, Zhang P, Zhang K, Cook JA, Song W, Virostek M, Slotabec LA, Rouhi N, Hazari M, Adenawoola MI, Liu X, Zhang H, Zhang G, Niewold EL, Li Q, Fang Y, Elhelaly WM, Sun XN, Guo X, Lemoff A, Deng Y, Gillette TG, Li J, Scherer PE, Wang ZV
High throughput screening identifies a trafficking corrector for long-QT syndrome associated KCNQ1 variants.
1. JCI Insight - published January 8, 2026
2. Clowes Moster KR, Vanoye CG, Chang-Gonzalez AC, Romaine IM, Stefanski KM, Wilkinson MC, Bauer JA, Hasaka TP, Days EL, Desai RR, Butcher KR, Sulikowski GA, Waterson AG, Meiler J, Ledwitch KV, George AL Jr, Sanders CR
Molecular mechanism of exchange coupling in CLC chloride/proton antiporters.
1. Nat Commun - published January 8, 2026
2. Aydin D, Chien CT, Kreiter J, Nava AR, Portasikova JM, Fojtik L, Sobecks BL, Mosquera C, Man P, Dror RO, Chiu W, Maduke M
Protocols to evaluate mutant specificity of an oncogene-targeting siRNA using orthogonal in vitro and in vivo approaches.
1. STAR Protoc - published January 8, 2026
2. Stanland LJ, Porrello A, Egli M, Pecot CV
RIG-I RNA agonist activates immunostimulatory macrophages to enhance checkpoint immunotherapy for glioblastoma.
1. bioRxiv - published January 8, 2026
2. Xu H, Lee S, Leser F, Fedorova O, Lu P, Song E, Touat M, Eichmann A, Iwasaki A, Pyle AM, Thomas JL
The essential function of the apical polar ring during the blood stage of Plasmodium falciparum.
1. bioRxiv - published January 8, 2026
2. Gurung P, Back PS, Ali I, Hernandez GM, Dvorin JD
EZH2 PROTACs outperform catalytic inhibitors in prostate cancer by targeting a methylation-independent function of PRC2.
1. Oncogene - published January 7, 2026
2. Xie W, Chu Q, Brea L, Zeng G, Wang Y, Lu X, Zheng M, Ley CR, Lei Z, Shi H, Zhu JL, Gong L, Martin MC, Shi X, Gritsina G, Grigorescu AA, Chandonnet H, Liu X, Zhao JC, Schiltz GE, Yu J
Expression, Purification, and Microscopy-Based Assays for Engineered Recombinant Tyrosinated, Detyrosinated, and Δ2 Human Tubulin.
1. Cytoskeleton (Hoboken) - published January 7, 2026
2. Chen J, Szyk A, Roll-Mecak A
Editorial overview: Cryo-electron microscopy (2025).
1. Curr Opin Struct Biol - published January 7, 2026
2. Brunger AT, Frank GA
Structural elucidation of the hexameric MmpS4-MmpL4 complex from Mycobacterium tuberculosis.
1. bioRxiv - published January 7, 2026
2. Earp JC, Lichti NP, Garaeva AA, Meikle V, Niederweis M, Seeger MA
Design of solubly expressed miniaturized SMART MHCs.
1. Proc Natl Acad Sci U S A - published January 6, 2026
2. White WL, Bai H, Kim CJ, Jude KM, Sun R, Guerrero L, Han X, Chen X, Chaudhuri A, Bonzanini JE, Sun Y, Onwuka AE, Wang N, Wang C, Nygren PÅ, Li X, Goreshnik I, Allen A, Levine PM, Kueh HY, Jewett MC, Sgourakis NG, Achour A, Garcia KC, Baker D
Memory B cell development in response to mRNA SARS-CoV-2 and nanoparticle immunization in mice.
1. Proc Natl Acad Sci U S A - published January 6, 2026
2. Wiatr M, Wang Z, Canis M, Hernandez B, Gazumyan A, Santos GSS, Shawraz S, Lee S, Bieniasz PD, Hatziioannou T, Muecksch F, Nussenzweig MC
A neutralizing APOA5 monoclonal antibody reduces amounts of lipoprotein lipase in capillaries and triggers hypertriglyceridemia.
1. Proc Natl Acad Sci U S A - published January 6, 2026
2. Yang Y, Beigneux AP, Lowe TL, Chen YQ, Xie K, Jung H, Tu Y, Yu RG, Scheithauer JL, Mehta S, Wu J, Alvarez L, Davidson WS, Birrane G, Remaley AT, Sviridov D, Ploug M, Zhen EY, Qian Y, Sloan JH, Siegel RW, Konrad RJ, Fong LG, Young SG
Tetraspanin TSP-12 and SUP-17/ADAM10 exhibit cell type-specific codependence for trafficking through the Golgi.
1. Proc Natl Acad Sci U S A - published January 6, 2026
2. Liu Z, Williams B, Wang L, Clark FK, Vignogna RC, Fromme JC, Liu J
Deletion of tonB1 in Pseudomonas aeruginosa impairs zinc homeostasis and pathogenicity.
1. Appl Environ Microbiol - published January 6, 2026
2. Li W, Zheng Y, Wang G, Cheng J, Xiao W, Ma X, Li P, Chazin WJ, Lin J
Advances in BRET probes for intracellular target engagement studies.
1. Nat Chem Biol - published January 6, 2026
2. Capener JL, Schwalm MP, Vasta JD, Michaud A, Teske KA, Marsiglia WM, Huber KVM, Dar AC, Knapp S, Axtman AD, Robers MB
PARG regulates the proteasomal degradation of TARG1.
1. Cell Rep - published January 6, 2026
2. Groslambert J, Buch-Larsen SC, Hendriks IA, Kurzbauer R, Elsborg JD, Chatrin C, Agnew T, Henfrey C, Tellier M, Prokhorova E, Hoang SM, Barosso-Gonzalez J, O'Sullivan RJ, Clausen T, Nielsen ML, Ahel I
Importins recognize the winged-helix fold of ETS transcription factors to mediate nuclear import.
1. bioRxiv - published January 6, 2026
2. McConville BM, Lankford K, Bernardes N, Walterscheid A, Valadez C, Brower A, Chook YM, Liszczak G
Close-up of vesicular ER exit sites by volume electron imaging using FIB-SEM.
1. J Cell Biol - published January 5, 2026
2. Nair A, Nair A, Stock P, Jain A, Somerville E, Sanyal A, Costa-Filho JI, Kirchhausen T
Actin arginylation alters myosin engagement and F-actin patterning despite structural conservation.
1. J Cell Biol - published January 5, 2026
2. Pinto CS, Bakker SE, Suchenko A, Kolodny IM, Hussain H, Hatano T, Sampath K, Chinthalapudi K, Heissler SM, Mishima M, Balasubramanian M
Towards a unified gating scheme for the CNBD ion channel family.
1. J Gen Physiol - published January 5, 2026
2. Lin JL, Chanda B
Pre-assembled complexes and allosteric effects: parallels between eukaryotic phosphorylation cascades and membrane fusion during herpesviral entry.
1. J Virol - published January 5, 2026
2. Gonzalez-Del Pino GL, Heldwein EE
β-barrels from short macrocyclic peptides.
1. Chem Commun (Camb) - published January 5, 2026
2. Dang VT, Martynowycz MW, McElheny D, Nguyen AI
Discovery of Coronavirus Main Protease Inhibitors with Enhanced Brain Exposure and Potent Oral Efficacy in SARS-CoV-2 and MERS Infection Models.
1. J Med Chem - published January 5, 2026
2. Lizzadro L, Li J, Taha TY, Degotte G, Detomasi TC, Zapatero-Belinchon FJ, Hantz ER, Huang S, Matsui Y, Henderson WR, McCann JT, Montano M, Rosecrans J, Torres Pomares DF, McGovern BL, Diaz-Tapia R, Benjamin J, Gordon ME, Suazo ID, Settineri NS, Diallo A, Krogan NJ, Shoichet BK, Verba KA, Albrecht R, García-Sastre A, White KM, Ott M, Craik CS, Renslo AR
Division of labor in trypanosome RNA processing and export through expanded Mex67 paralogs.
1. Nucleic Acids Res - published January 5, 2026
2. Obado SO, Fridy PC, Hegedűsová E, van Eeuwen T, Stein ME, Zhang W, Jensen BC, Chung C, Brillantes M, Glover L, Paris Z, Chait BT, Field MC, Rout MP
Depolymerizable Elastomeric Polyolefin Thermosets with Great Extensibility.
1. ACS Mater Lett - published January 5, 2026
2. Slor G, Khac QO, Julià LR, Ma Y, Stellacci F
New targets and procedures for validating the valence geometry of nucleic acid structures.
1. Nucleic Acids Res - published January 5, 2026
2. Černý J, Nicholls RA, Brzezinski D, Berman HM, Gilski M, Joosten RP, Kowiel M, Lawson CL, Moriarty NW, Richardson JS, Schneider B, Vonrhein C, Williams CJ, Jaskólski M, Egli M
FLARE: A Flow Cytometry-Based Fluorescent Assay for Measuring HSV-1 Nuclear Egress.
1. Bio Protoc - published January 5, 2026
2. Dai B, Polack L, Moores S, Calderon-Zavala AC, Heldwein EE
Reproducible Sample Preparation of Virus-Infected Cells for Cryo-FIB/ET Using Manual Plunge Freezing.
1. Bio Protoc - published January 5, 2026
2. Lavoie NR, Heldwein EE
Avl9 defines a family of GTPase-activating proteins that regulate diverse cell biological functions.
1. bioRxiv - published January 5, 2026
2. Vignogna RC, Fromme JC
Author Correction: Repulsions instruct synaptic partner matching in an olfactory circuit.
1. Nature - published January 4, 2026
2. Li Z, Lyu C, Xu C, Hu Y, Luginbuhl DJ, Caspi-Lebovic AB, Priest JM, Özkan E, Luo L
Structure and immunogenicity of an engineered soluble prefusion-stabilized EBV gB antigen.
1. Nat Commun - published January 3, 2026
2. McCool RS, Acreman CM, Powell AE, Picucci SI, Stieh DJ, Chou CW, Huynh J, Caruso H, Park S, O'Rear J, Chen JL, Palanski BA, Byrne PO, Sponholtz MR, Kim J, Ledgerwood JE, Weidenbacher PA, McLellan JS
Asymmetric envelope surface disposition of secreted protein YjbI controls bimodal antibiotic susceptibilities in C. crescentus.
1. EMBO J - published January 3, 2026
2. Costafrolaz J, Degeorges L, Panis G, Vallet SU, Velasco Gomariz M, Meireles FTP, Dal Peraro M, Fröhlich KS, Viollier PH
Bacterial ubiquitin ligase engineered for small molecule and protein target identification.
1. EMBO J - published January 3, 2026
2. Ye JS, Majumdar A, Park BC, Black MH, Hsieh TS, Osinski A, Servage KA, Kulkarni K, Naidoo J, Alto NM, Stratton MM, Alfandari D, Ready JM, Pawłowski K, Tomchick DR, Tagliabracci VS
TRIM2 E3 ligase substrate discovery reveals zinc-mediated regulation of TMEM106B in the endolysosomal pathway.
1. EMBO Rep - published January 3, 2026
2. Perez-Borrajero C, Stein F, Schweimer K, Rettel M, Schwarz JJ, Haberkant P, Lapouge K, Gayk J, Hoffmann T, Bhogaraju S, Noh KM, Savitski M, Mahamid J, Hennig J
Structural visualization of the molecular evolution of CRISPR-Cas9.
1. Nat Struct Mol Biol - published January 3, 2026
2. Nagahata N, Kato K, Yamada S, Kannan S, Okazaki S, Isayama Y, Hiraizumi M, Yamashita K, Koonin EV, Zhang F, Nishimasu H
Integrated fluorescence light microscopy-guided cryo-focused ion beam-milling for in situ montage cryo-ET.
1. Nat Protoc - published January 3, 2026
2. Yang JE, Vrbovská V, Mitchell JM, Franke T, Sibert BS, Larson MR, Hall AS, Rigort A, Mosher DF, Mitchels J, Wright ER
Uncovering mitotic ultrastructure in the native hair follicle using volume electron microscopy.
1. J Cell Sci - published January 3, 2026
2. Jadav N, Velamoor S, Hazelton N, Reader K, Harland D, Bostina M
Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition.
1. Immunity - published January 3, 2026
2. Navarro Negredo P, You J, Hauptschein M, Schroer AB, Richard DJ, Abhiraman GC, Tsai AP, Sun ED, Notarangelo G, Ramirez-Matias J, Zhou OY, Buckley MT, Malacon KE, Xu L, Sucharov J, Ramirez Lopez E, Picton L, Wyss-Coray T, Saxton RA, Fernandes RA, Villeda SA, Garcia KC, Brunet A
Horizontal transfer of post-translational modifiers brings evolutionary opportunity and challenges to a conserved translation factor.
1. BMC Biol - published January 3, 2026
2. Brewer TE, Kielkowski P, Stritzel J, Meier-Rosar F, Schlundt A, Lassak J
LPS-induced structural reorganization and polymerization drive noncanonical inflammasome activation.
1. Sci Adv - published January 2, 2026
2. Wang C, Lacey P, Tian T, Teran E, Liaqat M, Shivcharan S, Shumba P, He J, Rathinam VA, Wysocki VH, Ruan J
Quantitative Degradation Rate Assessment of bioPROTACs Based on Peptide Degrons, E3 Domains, Adapters and Conjugated Small Molecules.
1. ACS Chem Biol - published January 2, 2026
2. Vukovic D, Winkelvoß D, Udovcic A, Riermeier L, Jaime-Figueroa S, Crews CM, Plückthun A
SpatialDINO: A Self-Supervised 3D Vision Transformer that enables Segmentation and Tracking in Crowded Cellular Environments.
1. bioRxiv - published January 2, 2026
2. Lavaee A, Jain A, Scanavachi Moreira Campos G, Costa-Filho JI, Ingemansson A, Kirchhausen T
Predicting the protein interaction landscape of a free-living bacterium with pooled-AlphaFold3.
1. Mol Syst Biol - published January 2, 2026
2. Todor H, Kim LM, Jänes J, Burkhart HN, Darst SA, Beltrao P, Gross CA
Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells.
1. EMBO J - published January 2, 2026
2. Tesfamariam YM, Christensen MH, Diehl S, Klein T, Lingnau JM, Normann S, Hagelauer E, Herbert M, Reimer S, Joshi RP, Engels P, Pritzl S, Fontana P, Zillinger T, Hartmann G, Eis-Hübinger A, Lam MC, Walgenbach KJ, Meissner F, Wu H, Schmidt FI
Structure-Guided Design of Potent and Selective Covalent Inhibitors Targeting the SARS-CoV-2 Papain-like Protease.
1. J Med Chem - published January 2, 2026
2. Sharafi M, Teh WP, Green J, Charifson PS, Wang J, Pemberton OA, Nevins AM, Lye M, Liu X, Varca AC, Owen CD, Morsheimer K, Wacquiez A, Dawson C, Steuber C, Smith J, Girardi NM, Magin RS, Marto JA, Saeed M, Davey RA, Hardee D, Ng TI, Namchuk MN, Buhrlage SJ
Norepinephrine derepresses the Fur regulon of Neisseria gonorrhoeae to enable growth in iron-limited conditions.
1. J Bacteriol - published January 2, 2026
2. Westlake CS, Stoudenmire JL, Bhatia I, Perera YR, Krueger RM, Cornelissen CN, Chazin WJ, Kendall MM, Criss AK
BORC assemblies integrate BLOC-1 subunits to diversify endosomal trafficking functions.
1. Proc Natl Acad Sci U S A - published January 2, 2026
2. de Araujo MEG, J Amann S, Stasyk T, Schleiffer A, Rauch E, Flümann P, Singer II, Kremser L, Dostal V, Laopanupong T, Obojes N, Wallnöfer MH, Gradl FS, Kurzbauer R, Krebiehl C, Kofler S, Grishkovskaya I, Vogel GF, Hess MW, Sarg B, Clausen T, Haselbach D, Huber LA
Corrigendum to "E6 Proteins from Diverse Papillomaviruses Self-Associate Both In Vitro and In Vivo" [J. Mol. Biol. 396(1) (2010) 90-104].
1. J Mol Biol - published January 2, 2026
2. Zanier K, Ruhlmann C, Melin F, Masson M, M'hamed Ould Sidi AO, Bernard X, Fischer B, Brino L, Ristriani T, Rybin V, Baltzinger M, Pol SV, Hellwig P, Schultz P, Travé G
Erythrocyte Membrane Protein 3 (EMAP3) Is Exposed on the Surface of the Plasmodium berghei Infected Red Blood Cell.
1. Mol Microbiol - published January 2, 2026
2. Hernandez SRC, Rashpa R, Jonsdottir TK, Paoletta MS, Ter Beek J, Díaz MR, Krol JMM, Chevalley-Maurel S, Ishizaki T, Berntsson RP, Janse CJ, Franke-Fayard B, Brochet M, Bushell ESC
Shifting the PPARγ conformational ensemble toward a transcriptionally repressive state improves covalent inhibitor efficacy.
1. Elife - published January 2, 2026
2. Arifova L, MacTavish BS, Laughlin Z, Karadi Girdhar MN, Shang J, Li MH, Yu X, Zhu D, Kamenecka TM, Kojetin DJ
LetA defines a structurally distinct transporter family.
1. Nature - published January 2, 2026
2. Santarossa CC, Li Y, Yousef S, Hasdemir HS, Rodriguez CC, Haase MAB, Baek M, Coudray N, Pavek JG, Focke KN, Silverberg AL, Bautista C, Yeh JT, Marty MT, Baker D, Tajkhorshid E, Ekiert DC, Bhabha G
Lipids regulate epidermal growth factor receptor activation by its ligands.
1. Biochem Soc Trans - published January 2, 2026
2. Hutchison JM, Lemmon MA
A trans-synaptic IgLON adhesion molecular complex directly contacts and clusters a nicotinic receptor.
1. Nat Commun - published January 2, 2026
2. Mialon M, Patrash L, Granger L, Alexis W, Özkan E, Bessereau JL, Pinan-Lucarre B
A comprehensive view on r-protein binding and rRNA domain structuring during early eukaryotic ribosome formation.
1. Nucleic Acids Res - published January 2, 2026
2. Gerhalter M, Prattes M, Grundmann LE, Grishkovskaya I, Semeraro EF, Zisser G, Kotisch H, Merl-Pham J, Hauck SM, Haselbach D, Bergler H
Silencing lipid catabolism determines longevity in response to fasting.
1. Nat Commun - published January 2, 2026
2. Tatge L, Kim J, Solano Fonseca R, Feola K, Wall JM, Otuzoglu G, Johnson AC, Zuurbier KR, Oh J, Beheshti ST, Lopez VA, Daley AJ, Werner EG, Metang P, Arneaud SLB, Watterson A, McDonald JG, Tagliabracci VS, French ME, Douglas PM
Rapid Structural Analysis of Natural Products Using MicroED.
1. Small - published January 2, 2026
2. Lin J, Paz O, Unge J, Gonen T
RoboA reinforces planarian stem cell fate through FoxA and Anosmin1a.
1. Nat Commun - published January 2, 2026
2. Wang KT, Tsai FY, Chen YC, Judy CP, Weathers IE, Özkan E, Adler CE
A stabilized tandem antigen chimera that elicits potent malaria transmission-reducing activity.
1. Nat Commun - published January 2, 2026
2. Ivanochko D, Miura K, Hailemariam S, Ravichandran R, Song Y, Huang WC, Stoter R, Teelen K, van Gemert GJ, Leaf EM, Chan S, Men C, Semesi A, Shiu C, MacGill RS, Long CA, Jore MM, King NP, Lovell JF, Julien JP
In vitro reconstitution in membrane environment reveals critical lipid dependence of substrate S-acylation by protein palmitoyltransferase enzymes.
1. J Biol Chem - published January 2, 2026
2. Mondal T, Banerjee A
Structural basis for fork reversal and RAD51 regulation by the SCF ubiquitin ligase complex of F-box helicase 1.
1. Nat Commun - published January 2, 2026
2. Greer BH, Mendia-Garcia J, Mullins EA, Peacock EM, Haigh SK, Schiltz CJ, Aicart-Ramos C, Tsai MS, Cortez D, Moreno-Herrero F, Eichman BF
A highly dynamic mononuclear non-heme iron enzyme for the two-step isonitrile biosynthesis.
1. Nat Commun - published January 2, 2026
2. Ye N, Del Rio Flores A, Zhang W, Drennan CL
Mechanistic insights into SteAB regulation of cell wall hydrolase RipA in Mycobacterium tuberculosis.
1. mBio - published January 2, 2026
2. Carloni G, Gaday Q, Megrian D, Petit J, Martinez M, Sogues A, Ben Assaya M, Kakonyi M, Haouz A, Alzari PM, Wehenkel AM
The human RAD52 complex undergoes phase separation and facilitates bundling and end-to-end tethering of RAD51 presynaptic filaments.
1. Nucleic Acids Res - published January 2, 2026
2. Alshareedah I, Pangeni S, Dewan PA Jr, Honda M, Liao TW, Spies M, Ha T
Metabolically regulated proteasome supramolecular organization in situ.
1. Cell - published January 2, 2026
2. Tang X, Qu L, Wilfling F, Beck F, Ernst OP, Schulman BA, Baumeister W, Enenkel C
Rules of the road: how to turn off kinesin motors.
1. Biochem J - published January 2, 2026
2. Tan Z, Missman A, Cianfrocco MA
Cryo-EM structure revealed a novel F-actin binding motif in a Legionella pneumophila lysine fatty acyltransferase.
1. Elife - published January 2, 2026
2. Zeng WW, Komaniecki G, Liu J, Lin H, Mao Y
Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry.
1. EMBO J - published January 2, 2026
2. Pillan A, Ormancey P, Ben Choug C, Orlicky S, Tavernier N, Van Hove L, Ossareh-Nazari B, Joly N, Sicheri F, Lorca T, Pintard L
A prophage-encoded abortive infection protein preserves host and prophage spread.
1. Nature - published January 2, 2026
2. Sargen MR, Antine SP, Grabe GJ, Antonellis G, Ragucci AE, Li Y, Kranzusch PJ, Helaine S
Pre-assembly of biomolecular condensate seeds drives RSV replication.
1. Nature - published January 2, 2026
2. Ratnayake D, Galloux M, Boersma S, Noerenberg M, Sizun C, Sacristan C, Sourimant J, Lakerveld AJ, Gelderloos AT, Apperloo L, Demyanenko Y, Baars MJD, Banerjee R, Dreier B, Furler S, Mazur NI, Bont LJ, Mohammed S, Plückthun A, Éléouët JF, Kops GJPL, Castello A, van Kasteren PB, Rameix-Welti MA, Tanenbaum ME
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.
1. Cell - published January 2, 2026
2. Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Parra Bravo C, Bose RS, Travaglini KJ, Lam VL, Goodness D, Ta T, Dixon G, Marzette E, Jin J, Tian R, Tse E, Abskharon R, Pan HS, Carroll EC, Lawrence RE, Gestwicki JE, Rexach JE, Eisenberg DS, Kanaan NM, Southworth DR, Gross JD, Gan L, Swaney DL, Kampmann M
ClpC1-targeting peptide natural products differentially dysregulate the proteome of Mycobacterium tuberculosis.
1. Nat Commun - published January 2, 2026
2. Barter IK, Bedding MJ, Leodolter J, Maxwell JWC, Hawkins PME, Stevens MT, McNeil MB, Jowsey WJ, Wang T, Quan D, Junker S, Flórido M, Hesselson D, Cook GM, Clausen T, Britton WJ, Larance M, Payne RJ
Isolation of Antigen-Specific Nanobodies From Synthetic Libraries Using a Protein Selection Strategy That Combines MACS-Based Screening of YSD and FLI-TRAP.
1. Bio Protoc - published January 2, 2026
2. Thaiprayoon A, Chantarasorn Y, Oonanant W, Kasorn A, Longsompurana P, Tapaneeyakorn S, Riangrungroj P, Loison F, Kruse AC, DeLisa MP, Waraho-Zhmayev D
Engineered IgA-Fc fusion protein with bioactive nanobody neutralizes SARS-CoV-2 variants with mucosal delivery potential.
1. J Biol Chem - published January 2, 2026
2. Golonka RM, Intravaia LE, Shaqra AM, Li Q, Chen Y, Humphries F, Kurt-Yilmaz N, Fitzgerald KA, Schiffer CA, Wang Y, Cavacini LA
Constant trouble with prolines-navigating a global translation dilemma.
1. Nucleic Acids Res - published January 2, 2026
2. Lassak J, Stritzel J, Schlundt A, Brewer T
A conserved salt bridge network stabilizes the hepatic organic anion transporters OATP1B1 and OATP1B3.
1. J Biol Chem - published January 2, 2026
2. Barber D, Naughton F, van Hilten N, Grabe M, Paz A
Vaccine elicitation of HIV-1 neutralizing antibodies against both V2 apex and fusion peptide in rhesus macaques.
1. Cell Rep - published January 2, 2026
2. Duan H, Nkolola JP, Wang S, Chaudhari J, Teng IT, Lavine C, Parchment DK, Sellers GS, McKee K, O'Dell S, Choe M, Du H, Zhang B, Perez AAE, Rossler A, Lasrado N, Biju A, Becker JE, Carroll R, Carson AS, Henry AR, Morano NC, Mughal M, Rawi R, Roark RS, Schramm CA, Shen CH, Smith SC, Stephens T, Tsybovsky Y, Van Wazer DJ, Wang H, Yang Y, Rutten L, Langedijk JPM, Cheng C, Wang L, Douek DC, Koup RA, Mascola JR, Shapiro L, Zhou T, Doria-Rose NA, Korber B, Seaman MS, Pierson TC, Kwong PD, Barouch DH
Multidrug Resistance Transporter EmrE is Only Moderately Sensitive to Lipid Composition.
1. Biophys J - published January 2, 2026
2. Hiett AB, Hisao GS, Robinson AE, Morrison EA, Henzler-Wildman KA
Discovery of pyrrolopyrimidinone inhibitors of the BCL6-SMRT corepressor interaction.
1. Bioorg Med Chem - published January 2, 2026
2. Watson IDG, Morin JA, Subramanian PR, Chau AM, Prakesch MA, Wilson BJ, Morshed MM, Joseph BB, Uehling DE, Poda G, Abibi A, Chan M, Cheung H, Griffin C, Mao V, Marcellus R, Strathdee C, Subramaniam R, Thériault BL, Winston J, Aman A, Kiyota T, Undzys E, Kuntz DA, Pomroy NC, Mamai A, Privé GG, Al-Awar R, Isaac MB
Oriented Multivalent Display Drives Consistent Serum Immunodominance to the Ebola Virus Glycoprotein.
1. ACS Cent Sci - published January 2, 2026
2. Zheng C, Rubio AA, Vasquez S, Pham D, Pan Z, Barnes CO, Kim PS
Transcription co-inhibition alters drug resistance evolution and enhances Mycobacterium tuberculosis clearance from granulomas.
1. Nat Microbiol - published January 1, 2026
2. Bosch B, Munsamy-Govender V, Sarathy J, Lilic M, Olinares PDB, Eckartt KA, Nalam P, Lang M, Simon M, Richter A, Rock JM, Campbell EA
Dynamic interaction of the Yersinia pseudotuberculosis type three secretion system proteins LcrV and LcrG.
1. Protein Sci - published January 1, 2026
2. Mangu JCK, Rogne P, Mattsson J, Hultgren L, Gahlot KD, Lamy A, Berntsson RP, Johansson LB, Francis MS, Wolf-Watz M
Design and characterization of calprotectin tetramerization variants for probing the role of oligomerization in receptor activation.
1. Protein Sci - published January 1, 2026
2. Garcia V, D'Souza A, Kozlyuk N, Perera YR, Damo SM, Chazin WJ
License to Replicate: Mechanisms of Licensing Eukaryotic Origins for DNA Replication.
1. Bioessays - published January 1, 2026
2. Frisbie V, Bleichert F
An open axial channel of the AAA ClpXP protease enhances degradation of specific classes of protein substrates.
1. Protein Sci - published January 1, 2026
2. Lyu Y, Bolstad I, Davis JH, Sauer RT, Ghanbarpour A
Assessing the validity of leucine zipper constructs predicted by AlphaFold.
1. Protein Sci - published January 1, 2026
2. Mitic I, Rowell K, Litfin T, Michie KA, Jacques DA
Structural and functional specialization of Bordetella pertussis DsbA for pertussis toxin folding.
1. Protein Sci - published January 1, 2026
2. Penning S, Mitchell L, Hong Y, Cunliffe T, Subedi P, Wang G, Hor L, Totsika M, Paxman JJ, Heras B
T Cell Assay to Track Presentation of an Influenza Hemagglutinin Epitope Presented by the MHC-II Protein HLA-DR1.
1. Methods Mol Biol - published January 1, 2026
2. Ramesh KM, Lu L, Stern LJ
Mass spectrometry footprinting reveals microsomal CYP2A6 structural changes induced by interaction with its reductase flavin mononucleotide domain.
1. Drug Metab Dispos - published January 1, 2026
2. Chai M, Burris-Hiday SD, Rempel DL, Gross ML, Scott EE
Bridging the gap: When transcription meets translation.
1. FEBS J - published January 1, 2026
2. Rahil H, Weixlbaumer A
Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitors.
1. Nat Commun - published January 1, 2026
2. Bonsor DA, Finci LI, Potter JR, Young LC, Wall VE, Goldstein de Salazar R, Geis KR, Stephens T, Finney J, Nissley DV, McCormick F, Simanshu DK
Cyanopeptide Mixtures Induce Variable Synergistic and Antagonistic Effects Across Diverse Human Cell Lines.
1. Environ Toxicol - published January 1, 2026
2. Hart LN, Lev KL, Hefferan S, Premathilaka SH, Thenuwara SI, Isailovic D, Sherman DH, Dick GJ
EPOP restricts PRC2.1 targeting to chromatin by directly modulating enzyme complex dimerization.
1. Nat Commun - published January 1, 2026
2. Gong L, Liu X, Yang X, Yu Z, Bhat MY, Chen S, Lemoff A, Xing C, Liu X
A general one-step protocol to generate impermeable fluorescent HaloTag substrates for in situ live cell application and super-resolution imaging.
1. Nat Commun - published January 1, 2026
2. Roßmann K, Pabst U, Baciu BC, Sun S, Huhn C, Olesen CH, Kowald M, Tapp E, Bieck M, Birke R, Shields BC, Jeong P, Hong J, Tadross MR, Levitz J, Lehmann M, Lipstein N, Broichhagen J
The pathway-independent positive allosteric modulator C1 allows for the identification of active Y(4) receptor relevant positions.
1. Cell Mol Life Sci - published January 1, 2026
2. Schüß C, Vu O, Pelczyk T, Schubert M, Du Y, Stichel J, Weaver CD, Meiler J, Beck-Sickinger AG
Autopalmitoylation of IDH1-R132H regulates its neomorphic activity in cancer cells.
1. Nat Chem Biol - published January 1, 2026
2. Hu L, Lin J, Sun L, Berezuk AM, Tuttle KS, Zhu X, Seo HS, Dhe-Paganon S, Li P, Sun Y, Ni L, Zhang J, Tan D, Wakimoto H, Cahill DP, Bai X, Luo X, Asara JM, Subramaniam S, Shan Y, Wu X
PDX1 phosphorylation at S61 by mTORC1 links nutrient signaling to β cell function and metabolic disease.
1. Cell Rep - published January 1, 2026
2. Fan J, Zhang X, Zhang J, Zhao T, Burley SK, Zheng XFS
Microgravity reshapes bacteriophage-host coevolution aboard the International Space Station.
1. PLoS Biol - published January 1, 2026
2. Huss P, Chitboonthavisuk C, Meger A, Nishikawa K, Oates RP, Mills H, Holzhaus O, Raman S
A Modular Vaccine Platform Against SARS-CoV-2 Based on Self-Assembled Protein Nanoparticles.
1. Adv Sci (Weinh) - published January 1, 2026
2. Lee S, Jang Y, Kim Y, Shin Y, Song JJ, Kim M, Jon S
Insights from aquaporin structures into drug-resistant sleeping sickness.
1. Elife - published January 1, 2026
2. Matusevicius M, Corey RA, Gragera M, Yamashita K, Sprenger T, Ungogo M, Blaza JN, Castro-Hartmann P, Chirgadze DY, Chaitanya Vedithi S, Afanasyev P, Melero R, Warshamanage R, Gusach A, Carazo JM, Carrington M, Blundell T, Murshudov GN, Stansfeld PJ, Sansom MSP, De Koning HP, Tate CG, Weyand S
Cryo-EM structure of the vaccinia virus entry fusion complex reveals a multicomponent fusion machinery.
1. Sci Adv - published January 1, 2026
2. Lin CS, Li CA, Wang CH, Kao CF, Chiu HJ, Yeh MC, Gao HD, Ho MC, Lee HM, Chang W
Poly(ADP-ribose) glycohydrolase enforces p21 degradation via dePARylation to promote gastric cancer progression.
1. J Clin Invest - published January 1, 2026
2. Hu Y, Bao Q, Huang Y, Wang Y, Zhao X, Nan J, Meng Y, Deng M, Li Y, Zhuang Z, He H, Zu D, Zhong Y, Zhang C, Wang B, Li R, He Y, Wang Q, Liu M, Tainer JA, Shi Y, Cheng X, Jing J, Ye Z
Decoding the interconnected splicing patterns of hepatitis B virus and host using large language and deep learning models.
1. Microb Genom - published January 1, 2026
2. Lim CS, Brown CM
The structure of a thermostable phage's portal vertex and neck complex illuminates the headful maturation mechanism.
1. J Mol Biol - published January 1, 2026
2. Sedivy EL, Agnello E, Hobaugh JE, Ahsan R, Song K, Xu C, Kelch BA
The cotranslational cycle of the ribosome-bound Hsp70 homolog Ssb.
1. Nat Commun - published January 1, 2026
2. Zhang Y, Grundmann L, Vollmar L, Schimpf J, Hübscher V, Areeb M, Grishkovskaya I, Moddemann A, Werner K, Hugel T, Haselbach D, Rospert S
Cooperativity and communication between the active sites of the dimeric SARS-CoV-2 main protease.
1. Sci Adv - published January 1, 2026
2. Zvornicanin SN, Shaqra AM, Flynn J, Intravaia LE, Martinez HC, Jia W, Gupta DK, Moquin S, Dovala D, Bolon DN, Kelch BA, Schiffer CA, Yilmaz NK
Monoclonal antibodies for Mpox: protective targets and therapeutic potential.
1. Curr Opin HIV AIDS - published January 1, 2026
2. Guardado-Calvo P, Freund NT, Coelho CH
A potently neutralizing and protective human antibody targeting antigenic site V on RSV and hMPV fusion glycoprotein.
1. Cell Rep Med - published January 1, 2026
2. Abu-Shmais AA, Guo L, Khalil AM, Leonard SE, Miller RJ, Janke AK, Vukovich MJ, Bass LE, Suresh YP, Rush SA, Wolters RM, Kose N, Carnahan RH, Crowe JE Jr, Bonami RH, Mousa JJ, McLellan JS, Georgiev IS
In Memoriam: Professor Ruth Ann Austad Altschuld (1940-2025).
1. Protein J - published January 1, 2026
2. Narayan P, Berliner LJ, Narayan M
Cinnamic acid induces neurodevelopmental defects via PPARγ signaling in zebrafish.
1. Chem Biol Interact - published January 1, 2026
2. Peng L, Wang H, Li Y, Liu X, Chang K, Yi W, Wang B, Zeng N, Li Z, Wu C
Crystal structure of apo human spermidine synthase reveals dynamic rearrangement at the active site.
1. Struct Dyn - published January 1, 2026
2. Fagbohun OO, Canfield MA, Clinger JA
Structural basis for inhibition of SpyCas9 by the anti-CRISPR protein AcrIIA26.
1. Biochem J - published January 1, 2026
2. Bailey S, Zheng I, Learn B
Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity.
1. Nat Commun - published January 1, 2026
2. Schwartz I, Budroni V, Meyenberg M, Hodakova Z, Hornegger H, Hacker K, Schwartz S, Grabarczyk DB, Ehrmann JF, Scinicariello S, Haselbach D, Menche J, Clausen T, Karagöz GE, Versteeg GA
Structural analysis of OCT4 binding to human LIN28B nucleosomes.
1. Sci Rep - published January 1, 2026
2. Sinha KK, Halic M
Developing and Demonstrating a Lab Method for Quantifying Hair Exposure to Environmental Tobacco Smoke with a Forensic Perspective.
1. J Chem Educ - published January 1, 2026
2. Jones TZ, Trejo CJ, Mohammadi S, Sharifan H
The long noncoding RNA VIM-AS1 and nucleoporin Nup358/RanBP2 regulate SMAD nuclear accumulation during TGF-β signaling.
1. Nucleic Acids Res - published January 1, 2026
2. Rodrigues-Junior DM, Ali MM, Itoh Y, Ferreira MS, Heldin J, Fu H, Hoelz A, Heldin CH, Moustakas A
The proteomic blueprint of human aging: a 50-year, 13-tissue atlas.
1. Sci China Life Sci - published January 1, 2026
2. Fang MX, Fu TM
Dihydroartemisinin Promotes N1 Polarization of Tumor-Associated Neutrophils and Enhances Their Anti-Tumor Activity via Hub Gene Modulation.
1. Pharmaceuticals (Basel) - published January 1, 2026
2. Guo W, Liu Y, Ma W, Wang J, Chen B, Fan L
Mitochondrial DNA Instability and Neuroinflammation: Connecting the Dots Between Base Excision Repair and Neurodegenerative Disease.
1. Genes (Basel) - published January 1, 2026
2. Pittman MN, Nelsen MB, Thompson MK, Prakash A
From Prediction to Prevention: Using Text Mining and Explainable Machine Learning for Urban Bus Accident Analytics.
1. Risk Anal - published January 1, 2026
2. Chen B, Huang Y, Zheng Y, Liu X