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Supported Applications

mber-open

  • Description

    is a protein design framework for antibody binder design that leverages structure templates and sequence conditioning in backpropagation-based design through AlphaFold-Multimer. The tool enables format-specific binder design with a modular architecture built around three key modules: Template (prepares target structures and identifies hotspots), Trajectory (designs binder sequences using protein folding models and optimization), and Evaluation (assesses designed binders using various metrics). It includes a command-line interface for VHH (nanobody) binder design and has been experimentally validated with million-scale screening.

  • Usage

    To list all executables provided by mber-open, run: $ sbgrid-list mber-open Copy to clipboard

  • Installation

    Use the following command to install this title with the CLI client: $ sbgrid-cli install mber-open Copy to clipboard Available operating systems: Linux 64
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