Proteins at Work
Protein databanks are bursting with 3D structures that reveal molecules in vivid atomic details. But most of these molecules have been purified and studied in isolation, outside their native cellular environments. What researchers want to see now, in comparable detail, is how these molecules live and work together inside cells.
“The context-rich structural information, with molecular detail, is a cornerstone,” says software developer Shawn Zheng. “It is essential for understanding how a cell functions at the molecular level.”
Based in Redwood City, California, Zheng leads an algorithm development team at Biohub, a nonprofit research organization launched by the Chan Zuckerburg Initiative in 2016. As its name suggests, Biohub brings together biologists, physicists, microscopists, and software and hardware engineers in a focused effort to develop breakthrough imaging …
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