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Supported Applications

PXDesign

  • Description

    is a de novo protein-binder design suite combining a diffusion generator (PXDesign-d) with Protenix and AF2-IG confidence models for candidate selection and ranking. It supports YAML-defined target preparation, MSA-assisted extended runs, preview and generation-only modes, and output filtering with AF2-IG and Protenix success criteria to prioritize binders for wet-lab validation.

  • Usage

    To list all executables provided by PXDesign, run: $ sbgrid-list pxdesign Copy to clipboard

  • Installation

    Use the following command to install this title with the CLI client: $ sbgrid-cli install pxdesign Copy to clipboard Available operating systems: Linux 64

  • Primary Citation*

    Ren, Milong, Sun, Jinyuan, Guan, Jiaqi, Liu, Cong, Gong, Chengyue, Wang, Yuzhe, Wang, Lan, Cai, Qixu, Chen, Xinshi, Xiao, and Wenzhi. 2025. PXDesign: Fast, Modular, and Accurate De Novo Design of Protein Binders. bioRxiv.


    • *Full citation information available through

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